Toxicogenomics

Basic idea about Toxicogenomics

1. TOXICOGENOMICS By-Gouthaman P P

2. INTRODUCTION Toxicogenomics  is a subdiscipline of   pharmacogenomics collection, interpretation, and storage of information about gene and protein activity within a particular cell or tissue In response of a genome to environmental stressors and toxicants It combines genomics- transcriptomics , proteomics, metabolomics, and bioinformatics with conventional toxicology.

3. GOALS Understand the relationship between environmental stress and human disease susceptibility. Identify useful biomarkers of disease and exposure to toxic substances. Elucidate the molecular mechanisms of toxicity Database of environmental effects of toxic substances in biological systems

4. NCT (National Centre for Toxicogenomics) has created a public database of environmental effects of toxic substances in biological systems, CEBS Developed a encyclopaedia on toxicologically important genes, groups of genes, SNPs, and mutant and knockout phenotypes in animal models relevant to human health and environmental disease.

5. LIMITATIONS Difficulty in analysis of high density data . Difficulty in integration of data obtained by different technologies . Difficulty in linking “omics” data to specific adverse effects . Difficulty in translation statistical assessments into biological understanding . Limitations of incomplete functional annotation of genome data bases . Incomplete knowledge of functional pathways and networks, particularly trans-genome relationship .

6. CONCLUSION Assessment of problematic relationship between environmental exposure and disease. Identify biomarkers of incipient adverse effects I dentification of specific susceptibility polymorphism Facilitate the development on new drugs Helps improve the CEBS knowledge base, specially in human data.

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