Transdermal Drug Delivery System Samir.pptx

A novel approach of treatment.

1. Transdermal Drug Delivery System Presented By : Samir Goel M Pharm. Pharmaceutics 1 st Year Presented To : Dr Rajeshwar Sir Professor : Pharmaceutics Kumaun University Department of Pharmaceutical Sciences

2. Presentation Flow Introduction Structure of skin Penetration Process Factors influencing absorption through skin Components of TDDS Mechanism of action of TDDS Types of TDDS Evaluation Method Application Advantages Disadvantage

3. Introduction

4. Introduction

5. Introduction

6. Structure of Skin

7. Penetration Process

8. Intracellular Administration

9. Intercellular

10. Transappendageal

11. Factors influencing absorption through skin

12. Components of TDDS Polymer Matrix- Gelatin, Cellulose, Chitosan etc Drug/API- low melting point, short half life, low molecular weight, solubility in water and oil Permeation Enhancer- Surfactants, Fatty Acids, Cyclodextrin etc Adhesive- Polyacrylate, Polyisobutylene , Silicones Backing lamination- Polyesters, Elastomers Release Liner

13. Mechanism of action of TDDS

14. Mechanism of action of TDDS

15. Mechanism of action of TDDS

16. Mechanism of action of TDDS

17. Types of TDDS Drug in Adhesive System Reservoir System Matrix System Micro- reservoir System

18. Types of TDDS

19. Types of TDDS

20. Types of TDDS

21. Types of TDDS

22. Types of TDDS

23. Evaluation Method Thickness Uniformity of weight- Random checking of batches Drug content determination Content uniformity Moisture content- % moisture content=initial wt - final wt x 100 Moisture Uptake Folding endurance Rolling ball test Invitro test- Franz diffusion cell

24. Application

25. Advantages Avoid first pass effect Consistent serum level of drug Non invasive Choice of termination Novel option Self administration Gastrointestinal upsets avoided Narrow therapeutic window Extended therapy Continued Drug administration

26. Disadvantages Skin irritation and hypersensitivity Slow permeation of hydrophilic property Not suitable for high drug doses Not suitable for low potent drugs High cost