TYPES OF COMPLEMENT PATHWAYS- IMMUNOLOGY

CLASSICAL,ALTERNATIVE,LECTIN PATHWAYS

1. VIVEKANANDHA Submitted to Ms.S.Anandhi Assistant Professor PG & Research Department of Biotechnology Vivekanandha Arts and Science College For Women Sankari Submitted by V.NIVETHA II- B.SC BIOTECHNOLOGY PG & Research Department of Biotechnology Vivekanandha Arts and Science College For Women Sankari Assignment on “ types of pathways” Subject: immune system and immunotechnology ARTS & SCIENCE COLLEGE FOR WOMEN [An ISO 9001:2015 Certified Institution] (Affiliated to Periyar University, Salem Recognised Under Section 2(f) &12(B) of the UGC Act, 1956) Veerachipalayam , Sankari West (Post) – 637 303, Sankari Tk , Salem Dt., Tamil Nadu PG & RESEARCH DEPARTMENT OF BIOTECHNOLOGY

2. Types of complement pathways

3. Synopsis INTRODUCTION THREE TYPES OF PATHWAYS CLASSICAL PATHWAYS ALTERNATIVE PATHWAYS LECTIN PATHWAYS STRUCTURE OF PATHWAYS CONCLUSION

4. Introduction There are three pathways of complement activation: the classical pathway, which is triggered directly by pathogen or indirectly by antibody binding to the pathogen surface; the MB-lectin pathway; and the alternative pathway, which also provides an amplification loop for the other two pathways.

5. Classical pathway The classical pathway is one of three activation pathways of the complement system, which is a major contributor to the defense of infections, clearance of pathogens, removal of apoptotic/necrotic cells, and maintenance of homeostasis.

6. Alternative pathways The alternative pathway is one of three complement pathways that opsonize and kill pathogens. This pathway is activated by viruses, fungi, bacteria, parasites, cobra venom, immunoglobulin A, and polysaccharides and forms an important part of the defense mechanism independent of the immune response.

7. Lectin pathways The lectin pathway is a third mechanism for activating complement. It is actually a minor variation of the classical pathway. It is initiated by mannose binding protein attaching to carbohydrate moieties found on the surfaces of some bacteria. It proceeds identically to the classical pathway from the C2 stage onward.

8. Classical pathway structure

9. Classical pathway structure

10. Alternative pathways structure

11. Lectin pathways structure

12. COMPLEMENT PATHWAYS

13. Conclusion In conclusion, complement is a multifaceted and robust effector, which bridges the innate and adaptive immune systems. It is vital to host defense , and the extent of its influence is becoming increasingly appreciated as additional information regarding the far-reaching effects of its activation is uncovered.

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