ulcersoftheintestinepatjology170305141940.pptx

ulcers of the intestine and their patjology on microscopic view and gross view

1. Ulcers of Intestine

2. SLOs Classification Salient features Pathogenesis Gross Histology Complications

3. Ulcer “Ulcer is a breach in the continuity of skin, epithelium or mucous membrane caused by sloughing out of inflammed necrotic tissue”

4. Intestinal Ulcers

5. Duodenal Peptic Ulcer

6. Pathogenesis

7. Gross Necrotic slough Rounded edge Sharp edge

8. Histopathology Necrotic slough Non-specific inflammtion Granulation tissue Fibrosis

9. Complications

10. Typhoid ulcer Salmonella typhimurium Salmonella paratyphi

11. Pathogenesis

12. Gross Peyer’s patches Oval ulcers Long axis

13. Histopathology Aggregates of macrophages Typhoid nodules

14. Complications

15. Tuberculosis ulcer Mycobacterium tuberculosis Mycobacterium bovis

16. Pathogenesis

17. Gross Transverse ulcers Short axis Direction of lymphatics

18. Histopathology Epithelioid cell granuloma

19. Complications

20. Amoebic ulcer Entamoeba histolytica

21. Pathogenesis

22. Gross Pin –point ulcers Nodules

23. Histopathology Flask shaped ulcer

24. Complications

25. Pseudmembranous colitis Clostridium difficile

26. Pathogenesis

27. Gross Cap lesion Pseudomembrane

28. Histopathology Mushroom / Volcanic eruption

29. Complications

30. CMV Colitis

31. Pathogenesis

32. Gross Erythematous base Haemorrhagic

33. Histopathology Inflammation CMV inclusion

34. Complications

35. Ulcerative colitis

36. Pathogenesis

37. Gross Continuous Wide ulcers Pseudopolyps

38. Histopathology Blunting and distortion of villi Cryptitis Crypt abscess

39. Complications

40. Crohn’s disease

41. Pathogenesis

42. Gross Skip lesions Serpengious ulcers Cobblestone

43. Histopathology Transmural Fissure Granuloma

44. Complications

45. Graft versus host disease

46. Pathogenesis

47. Gross Pin point Haemorrhagic

48. Histopathology Apoptosis Intra-epithelial lymphocytes

49. Complications

50. Carcinoma

51. Pathogenesis

52. Gross Ulceroproliferative Rolled up indurated

53. Histopathology Irregular glands Dysplasia

54. Complications

55. Summarise

56. Questions