unearthing the potential-G.Vaishnu Devi.pdf

This aims at moving towards potential metals and mineral based siddha drugs which are highly important in curing chronic disease with less dosage of medicine, aiming at holistic approach.

1. Dr.G.VaishnuDevi,
PG scholar,
GunapadamDept,
Government siddha medical college
Palayamkottai.

2. 1. Relief from suffering/pain
2. Disease prevention
3. Cure and treatment
4. Improved health outcomes
5. Enhanced quality of life.
6. Increased lifespan.
7. Economic benefits
8. Social and emotional well-
being
9. Scientific progress
10. Hope and reassurance

3. Natural products are used extensively
throughout the world, at least in 70% of
drugs available in the global market.
However, there is a great threat to
biodiversitydue to overharvesting raw
materials for herbal medicines and health
care products. Since many medicinal
plants are also in the endangered list, it is
better to adaptMetals and Mineral based
medicine,which is practiced traditionally
in India. An ancient system of traditional
Indian medicine ‘Siddha’uses metals,
metalloids and mineralsthat comprises
toxic and heavy elements such as lead,
mercury and arsenic.
Gunapadam
Mooligai
herbs
Jeevam
Animal
products
Thathu
Metals and
minerals

5. Addressing these challenges requires collaboration among
pharmacologists, chemists, biologists, and clinicians to unlock the therapeutic
potential of metals and mineral baseddrugs.

6. ThebranchorscienceofMercurybasedmedicinesarecalledas
Rasasasthra-
ரச சாத்?ரம்
,
RasaOushadam–
ரச ஔடதம்
,
Rasavignanam–
ரச ?ஞ்ஞானம்
,
Rasavaithiyam–
ரச ைவத்?யம்
,
Rasavaatham–
ரசவாதம் etc…
InSiddha,Mercuryisextensivelyusedinthepreparationofmedicinesafter
purification.
MercuryisalsousedintheAlchemicalandrejuvenationmedicine
preparations.
Rasameanselixiroflifeandthewordisattributedtothemostimportant
factorresponsibleforlifeinvariousfieldsoflifeofknowledge.
InphysiologyitisthefirstandforemostDhatoo(tissue)withoutwhichno
furtherprocesscantakeplace.
Intheherbaldomainitistheessenceofasubstance.
Thesamemeaningisimpliedtomercurybydenotingitasrasa‘ராசா‘of
themineralkingdomorinotherwordsthemetalofutmostimportancehaving
distinctpropertiesanduniquenatureisgiventhetermRasa.

7. Why mercury based medicines?
SiddharAgathiyarhasgivenathumbruleforselectingmedicinesfor
treatmentasfollows,
“ ேவர் பார் தைழ பார் ?ஞ்?னால்ெமல்ல ெமல்ல
பற்ப ெசந்?ரம் பாேர! ”
Even though pure herbal based medicines are effective, Mercury based siddha
medicines like parpam, mezhuguand chendooramare preferred for
following
Vast
Utility
Fast
Action
Highly
potent.
Cures
chronic
disease
Easy
to
consu
me
Longer
Shelf
life
Smaller
dose
enough
Rejuven
ation
Medicin
e

8. Importance of Mercury.
ஆச்சப்பா ?தமங்ேக இல்லா?ட்டால்
அப்பேன ெக?னெமன்ற ?ளிைகேபாச்?
ேபாச்சப்பா வாதெமன்ற ெசால்?ம்ேபாச்?
ேபரான காய?த்? ேப?ம்ேபாச்?
?ச்சப்பா அற்ற?டம் ேநாக்?ற?ம்ேபாச்?
?தண்ட ?த்தெரன்ற ேப?ம்ேபாச்?
ஓச்சப்பா மந்?ரமாஞ் ?த்?ேபாச்?
ஓேகாேகா ?த்ெதல்லாம் ஓ?ப்ேபாச்ேச.
-ெகாங்கணர் ந?க்காண்டம் -500 (355)

Explanation:Withoutmercury,onecannotprepareanimatedpillswhichwillhelpinspace
travel,
Withoutmercury,alchemyisnotpossible,
Withoutmercury,rejuvenationorattainingsiddhiisnotpossible,
Withoutmercury,mantra
(மணி மந்?ரம் ஔஷதம் )

isnotpossible,
Withoutmercury,eventhenameofsiddhaislost,
Withoutthisonecannotattainsiddhi.

9. Therearemanyprocessesinrasasathiram,whichplayaveryimportantrole
inmakingthesiddhametallicandmineralpreparationsfreeoftoxicityandinmaking
themhighlyabsorbableintothehumansystemascomparedtothemetallicandmineral
compoundspreparedbymodernchemicalmethods.
.
Mercury –the foremost drug of rasa
sasthra, which preserves its mystical links with
tantraand alchemy, is considered as a living
substance or a living being.
In the process of converting it into a rejuvenating
medicine it goes through all of the same processes
as the siddha who seeks salvation.
First the mercury is‘awakened’, made
‘hungry’, it is fed, made to ‘swoon’ and lastly
‘killed’. Here the word ‘killing’ refers to
incineration

10. Various process involved in purification of mercury in Siddha System
are
•பதங்கம்
Sublimation
•?ரித்ெத?த்தல்
Extraction
•ெந?ப்?ற் ேகாடாதப ? கட்?த்தல்
Fixation
•வாைல?ல் இ?தல்
Distillation
•ஊட்டங்க் ெகா?த்தல்
Calcination
•?ட??த்தல்
Cibation
•உைறயச் ெசய்ைக
Congelation
•உறவாக் ?ைக
Combination or conjugation
•உ?க்?ைக
Fusion
•கைரத்தல்
Dissolution
•நீராக்கல்
Liquification
•ைவப்? அல்ல? உண்டாக்கல்
Fabrication
•அைரத்தல்
Levigation
•?ைச???த்தல்
Cuppellation
•சாரைண ெகா?த்தல்
Animation or vivification
•நீற்றல்
Incineration
•?ரி?ைன ப?த்?ைக
Separation

11. Few of the Names of Mercurial preparations:
Rasagendhimezhu–
ரசெகந்? ெம??.
Rasakattu–
ரசக்கட்?.
Rasa karpurakattu–
ரசக் கற்?ர கட்?.
Rasa parpam–
ரசப்பற்பம்.
Chandamaaruthachendooram–
சண்டாமா ?த ெசந்?ரம்
.
Rasa chendooram–
ரச ெசந்?ரம்
.
Rasa kuligai–
ரசக் ?ளிைககள்
.
SurakaangishaMathirai–
?ரகாங்?ஷ மாத்?ைரகள்
.
Rasa pathangam–
ரசப் பதங்கம்
.
Rasamani–
ரச மணிகள்
etc…

12. In the preparation of VeeraRasa Padhangan, a metal-based formulation,
mercury is extracted from mercuric perchlorideand then subjected to sublimation.
At this point, the process was paused, and a sample was sent for X-ray diffraction
(XRD) analysis to identify the compound formed. Following the XRD study, the
preparation continued with the KuppiEripputechnique, which was carried out for
12 hours
VEERAM
MERCURIC PER CHLORIDE
CALOMEL
Purification-boiling in
tender coconut+camphor
mixture without touching
it
Purified VEERAM

14. Jess Clark (May 24, 2018). How to Sublime Mercury: Reading Like a Philosopher in
Medieval Europe.The Recipes Project. Retrieved August 16, 2024 from
https://doi.org/10.58079/td3r
SOURCE:

15. X-Ray Diffraction (XRD) Analysis:
The XRD powder diffraction pattern of Intermediate product of VRP can be recorded on X-ray
diffractometer(Siemens D5005 Diffractometer) using CuKaradiation, Lamda= 1.5406 Angstrom]
over the range 10.0-80.0[degrees].
Diffractogramshowing peaks of crystalline phase of Intermediate product of VEERA RASA
PATHANGAM

16. 2 Theta
[ 2θin
degrees]
OrientationCrystalline size
(nm)
Lattice
Constant
(Angstrom)
Cell
Volume
(Angstrom
cube)
21.45
28.22
43.85
46.14
52.91
75.71
(111)
(200)
(220)
(311)
(410)
(511)
19.15
11.39
13.90
16.64
18.22
19.00
4.0895
4.0980
4.0877
4.0875
4.0912
4.0854
68.3928
68.8201
68.3025
68.2925
68.2712
68.2314

17. Experimentaldiffraction angle
[ 2θin degrees]
Standard diffraction angle [ 2θin degrees]
ICDDHgCl2 : 00-024-0719
21.450 21.620
43.853 43.860
46.143 46.835
Three peaks at 2θvalues are intermediate product of VRP is
compared with Standard diffraction angle (2θin degrees)
ICDD Pure HgCl2 :00-024-0719

19. Justificationfor Pharmaceutical industries to turn towards Siddha mineral metal-based
formulations:
1. Growing demand for natural products.
2. Untapped potential
3. Cost savings: Lower R&D costs
4. Diversification.
5. Global market opportunities.
6. Sustainability.
7. Innovative solutions.
By embracing Siddha mineral metal-based formulations, Pharmaceutical
industries can Promote sustainable and eco-friendly practices-Serve mankind with effective,
holistic health solutions ,.
Conventional Pharmaceuticals
1.Syntheticchemicals.
2.Single-targetapproach
3.Short-termfocus
4.Patent-driven
5.Highcosts:R&D.
Siddha Metal,Mineral-Based
Formulations
1. Natural ingredients.
2. Multi-target approach.
3. Holistic approach.
4. Traditional knowledge
5. Cost-effective: R & D.

20. Through the application of drug design and development principles the Siddha science
of metal and mineral preparations, has been validated through rigorous research and
testing. The integration of these two disciplines has opened new avenues for the
discovery of novel treatments for various diseases.
As we move forward, let us continue to harness the power of Siddha metal
and mineral preparations, backed by scientific evidence, to improve human health and
wellbeing. This shift can lead to a more inclusive, integrative approach to combining the
best of traditional wisdom with modern scientific expertise . This conclusion highlights
the fusion of traditional Siddha knowledge with modern pharmaceutical sciences,
emphasizing the potential for innovative solution and the importance of evidence-
based research.