Unit 4 transdermal drug delivary system .pptx

TDDS

1. T ransdermal D rug D elivery S ystem TDDS sanjo cps palakkad

2. Definition: Transdermal drug delivery is defined as a self contained discrete dosage form, which when applied to the intact skin, will deliver the drug at a controlled rate to the systemic circulation. Definition : Transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentrations over a prolonged period of time. 2 Transdermal drug delivery system sanjo cps palakkad

3. POTENTIAL BENEFITS OF TRANSDERMAL DRUG DELIVERY (ADVANTAGES) Easy to use. Avoid GIT absorption problems for drugs. Avoids FP hepatic metab olism of drugs. More improved and convenient patient compliance . Rapid termination in case of toxicity is possible. Self medication is possible. Reduces frequency of dosing. Maintains therapeutic level for 1 to 7 days. Controlled delivery resulting in more reliable and predictable blood levels . 3 sanjo cps palakkad

4. DISADVANTAGES Daily dose of more than 10mg is not possible. Local irritation is a major problem. Drug requiring high blood levels are unsuitable. Drug with long half life can not be formulated in TDDS. Uncomfortable to wear. May not be economical. Barrier function changes from person to person and within the same person. Heat, cold, sweating (perspiring) and showering prevent the patch from sticking to the surface of the skin for more than one day. A new patch has to be applied daily. 4 sanjo cps palakkad

5. 5 Routes of drug absorption through skin sanjo cps palakkad

6. Pathways of drug penetration 1.Stratum corneum 2.Transfolicular 3.Sweat glands sanjo cps palakkad

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8. Needle-free Jet Injectors sanjo cps palakkad

9. FACTORS AFFECTING TRANSDERMAL PERMEABILITY Physico chemical properties of parent molecule Physico chemical properties of drug delivery system Physiological and pathological condition of skin Biological factors Formulation factors sanjo cps palakkad

10. BASIC COMPONENTS OF TRANSDERMAL DRUG DELIVERY SYSTEM Drug Polymer Matrix Penetration Enhancers Other Recipients -Rate controlling membrane -Adhesive -Release liner -Backing membrane sanjo cps palakkad

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12. 12 Basic components of Transdermal drug delivery 12 sanjo cps palakkad

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16. Topical application-absorption & action of drugs SYSTEMIC DRUG IN TARGET TISSUE DRUG IN BLOOD CIRCULATION DISTRIBUTION ELIMINATION PHARMACOLOGICAL RESPONSE TOPICAL ABSORPTION DRUG IN DELIVERY SYSTEM DRUG IN SKIN SECRETION FLUIDS, SWEAT, SEBUM, pH 4.5--5.5 TRANSDERMAL LOCALIZED RELEASE 16 sanjo cps palakkad

17. FORMULATION APPROACHES FOR DEVELOPMENT OF TRANSDERMAL DRUG DELIVERY SYSTEM 17 sanjo cps palakkad

18. sanjo cps palakkad POLYMER MEMBRANE PERMEATION CONTROLLED SYSTEM POLYMER MATRIX DIFFUSION CONTROLLED TDDS SYSTEM ADHESIVE DISPERSION-TYPE SYSTEM GRADIENT CONTROLLED TDDS MICRORESERVIOR TYPE OR MICROSEALED DISSOLUTION CONTROLLED SYSTEM

19. 1. POLYMER MEMBRANE PERMEATION CONTROLLED SYSTEM 19 sanjo cps palakkad

20. 2. POLYMER MATRIX DIFFUSION CONTROLLED TDDS SYSTEM 20 20 sanjo cps palakkad

21. 3. ADHESIVE DISPERSION-TYPE SYSTEM 21 sanjo cps palakkad

22. 4. GRADIENT CONTROLLED TDDS Drug – impermeable metallic plastic laminate Drug reservoir gradient layers R 1 >R 2 >R 3 R 1 R 1 R 2 R 3 } 22 sanjo cps palakkad

23. 5. MICRORESERVIOR TYPE OR MICROSEALED DISSOLUTION CONTROLLED SYSTEM rim 23 sanjo cps palakkad

24. ADVANCED RESEARCHES MICROARRAY NEEDLE Advanced micro-needle Patch transdermal system allowing continuous delivery through the skin of proteins and water-soluble drugs. 24 sanjo cps palakkad

25. 25 MICRONEEDLE ARRAY sanjo cps palakkad

26. sanjo cps palakkad Ultrasound to Enhance Skin Permeability

27. 27 Find an appropriate place to put the patch sanjo cps palakkad

28. sanjo cps palakkad TARGETED DRUG DELIVERY SYSTEM TDDS

29. A Targeted drug delivery system is preferred in the following situations sanjo cps palakkad

30. SMART DRUG DELIVERY Method of delivering medication to a patient medication to a patient in a manner that increase the concentration of the medication in some parts of the body relative to other sanjo cps palakkad

31. PROPERTIES OF TARGETED DRUG DELIVERY sanjo cps palakkad It should be nontoxic, biodegradable, biocompatible and physicochemical stable invivo and invitro  should have uniform capillary distribution .  Predictable and Controllable and rate of drug release.  Drug release should not influence the drug delivery .  Therapeutic amount of drug release .  Minimal drug leakage during transit  Carrier used should be biodegradable modulation of diseased state .

32. DEVICES BASED ON NANOTECHNOLOGY Nano tubes Nano shells Quantum dots Dendrimers sanjo cps palakkad

33. NANOPARTICLES Advantages Particle size and surface properties of nanoparticles can be easily manipulated control and prolong release of the drug during the transportation choice of matrix constituents . Specific targeting to particular site can be achieved sanjo cps palakkad

34. Nano tubes They are hollow cylinder made of carbon , atoms which can be filled and sealed for potential drug delivery. Help to identify DNA changes associated with cancer cells Nano shells Nano shells are hollow silica spheres covered with gold. Has potential for targeting cancerous drug Quantum dots These are tiny crystals that glow when these are stimulated by ultravioletlight . Dendrimers Dendrimers are new class of macromolecules which have a symmetric core and form the 3-D spherical structure . sanjo cps palakkad

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