Vaccines Bioprocess Development ppt.pptx

Vaccine Bioprocess Development

1. Vaccines

2. What is a Vaccine? A vaccine is  a preparation that helps your body's immune system recognize and fight off harmful germs and diseases Examples: Viral Vaccines – Flu, Covid- 1; Bacterial Vaccines – Tetanus, Diptheria, Pertussis etc.

3. Why Do We Need Vaccines? Helps the immune system counter infections faster and a more effective manner, Prevents re-infection

4. Stages of Vaccine Development

5. Stages of Vaccine Development 6 to 9 Months 6 to 9 Months Timelines for Covid Vaccines (How it is made so Rapidly?)

6. Traditional Vaccines - Egg Based Technology Examples of egg based vaccines – Most Flu shots and nasal spray flu Vaccines, Yellow Fever Vaccine , Q- Fever Vaccine

7. Egg Based Technology Vs Cell Based Technology

8. Egg Based Technology Vs Cell Based Technology

9. Types of Vaccines

10. Production of Vaccines - Bioreactors Bioreactors play an important role in the production of largescale viral vaccines in cell culture Early bioreactors was mainly based on stirring bioreactors for microbial fermentation – Shear Forces!!! Key to the large-scale industrialization and commercialization of cell culture technology lies in designing a suitable bioreactor It provides a suitable growth environment for cells, determines the quality and yield of cultured cells, and affects the vaccine’s production efficiency and product quality Cell Culture Reactors Mechanical Stirring Reactors Airlift Bioreactors Hollow Fiber Reactors

11. Production of Vaccines - Bioreactors Cell Culture Reactors According to how the cells are cultured, these bioreactors can be divided into three types Adherent Culture Bioreactors Embedded Culture Bioreactors Suspension Culture Bioreactors