VITAMIN D. Pharmacology description in short

Vitamin D
Introduction
Source of vit D
Pharmacokinetics
Vitamin D deficiency disease

1. PRESENTED BY:-NIKITA PANDURANG PAWAR
COLLEGE NAME:- GANDHI NATHA RANGJI COLLEGE OF PHARMACY, SOLAPUR
DRUG INFLUENCE ON
ENDOCRINE SYSTEM AND
VITAMIN D
Understanding the impact on bone health and calcium
homeostasis

2. ENDOCRINE SYSTEM
It is the complex network of glands and organs that produce and release
hormones into the blood stream .
These hormones act as a chemical messenger ,regulating ,various
physiological process and maintaining homeostasis ,
which is the internal balance of body.
ROLE
Hormone production , Stress response ,Growth and development , Blood
sugar regulation , etc.
Vitamin D is vital for strong bones and calcium absorption . It ensures
optimal bone health and helps to prevent` conditions like osteoporosis
by facilitatingthe absorption of calcium in the body.

3. Vitamin D is a crucial hormone
Vitamin D is crucial as its function like hormone in the body, influencing various physiological processes such as,
1)Calcium Absorption:- vitamin D enhances the absorption of calcium in
the intestines ensuring a sufficient supply for bone health and other
body functions.
2)Bone Health :- By regulating calcium and phosphorus levels, vitamin D
supports proper levels , vitamin D supports proper Bone Mineralization ,
preventing conditions like osteoporosis
3)Immune system modulation:- Vitamin D plays a role in immune system
function influencing responses to immune balance
4)Cell Growth And Differentiation:- It is involved in cellular processes,
including the regulation of cell growth and differentiation

4. VITAMIN D SOURCES
Vitamin D can be obtained from various sources including :-
1.Sunlight :- The skin produces vitamin D when exposed to sunlight spending time outdoors ,
especially during midday allows the body to synthesize vitamin D
2.Fatty Fish :- salmon, mackerel and tuna are rich sources of vitamin D
3.Egg Yolks :- Egg yolks contain vitamin D , but the amount varies depending on the diet of
the hens
4.Fortified Foods :- some foods such a milk , orange juice , and breakfast cereals , are fortified
with vitamin D
5.Cod Liver Oil:- A traditional supplement , cod liver oil is a concentrated source of vitamin D
6.Supplements:- vitamin D Supplements are available and may be recommendedespecially
for individuals with limited sun exposure or specific dietary restrictions
Maintain a balanced diet and appropriate sun exposure are key to obtaining sufficient vitamin
D however, individual needs may vary and consultation with a healthcare professional can
provide personalized advice .

5. VITAMIN D ROLE IN CALCIUM ABSORBTION
Vitamin D plays a crucial role in calcium absorption by influencing the
absorption of dietary calcium in the small intestine
A) Intestinal Absorption – In the small intestine , calcium is absorbed from the
food we consume
B) Vitamin D Activation – Vitamin D undergoes a series of transformation ,
including activation in the skin through exposure to sunlight or
through dietary intake
C) Calcium Binding Proteins- Active vitamin D enhances the synthesis of calcium
binding protein in the cells lining the small
intestine D) Transport Of Calcium – These calcium
binding proteins facilitate the transportof calcium across the intestinal lining
into bloodstream
E) Blood Circulation – Once in the bloodstream , calcium is then available for use
in various bodily functions, particularly in maintaining bone
health

6. PHARMACOKINETICS
Vitamin D is well absorbed from the intestine in the presence of bile
salts, mainly through lymphatics absorptions of the D3 form is
somewhat better than that of D2
In the circulation , it is bound to a specific alpha globulin and is
stored in the body , mostly in adipose tissue. It is hydroxylated in the
liver to active and active and inactive metabolites . The t1/2of
different form varies from 1-18 days: 25-OHD3 , having the longest
t1/2 , constitutes the primary circulating form. Calcitriol is cleared
rapidly.
Metabolites of vitamin D are excreted mainly in bile.

7. Vitamin D Deficiency Diseases
1.Rickets – It is more prevalent in growing children because vit D is crucial for proper
absorption of calcium and phosphorus, essential for bone development
2.Osteomalacia- Softening of bones in adults due insufficient of mineralization
3.Osteoporosis- Decreased bone density risk of fractures increased
4.Muscle weakness- vit D plays role in muscle function ,and deficiency leads to weakness
5.Crohn s diseases- chronic inflammatory bowel disease (IBD) that can affect any part of the
digestive tract from mouth to anus . It often leads to inflammation in small intestine and
colon
Drugs used in primary treatment of vit D deficiency
1.Cholecalciferol(vit D3)
2.Ergocalciferol(vit D2)
3.Calcitriol
4.Vit D analogs like calcipotriene
5.Combination supplements

8. THANK
YOU