NEC: neural epitelial cells RGC: Radial glia cells N: neurons IPC: intermediate progenitor cells SVZ: Subventricular zone SNP: Short neural progenitors OSVZ: Outer subventricular zone CP: Cortical plate IZ: Intermediate zone VZ: Ventricular zone Diverse populations of excitatory neuron progenitor cells in the mouse neocortex Neurona Glia radial C. madre
Desarrollo del Sistema Nervioso Central Nature Vol 468 pg 214 (2010). Astrocitos protoplásmicos Astrocitos fibrilares
NeuN (Neuronal nuclei), otherwise as Fox3, is a RNA binding protein . It is highly specific for post-mitotic neurons. Some neurons don’t express this marker MAP2 (microtubule-associated protein 2) Interacts with tubulin . Beta III tubulin : expression limited to neurons. PSD 93/95 Neuron specific enolase Neurofilaments 160 kD
Tis21-GFP expression in the course of adult hippocampal neurogenesis. Cerebral Cortex , 2010 Vol:20 (2): 304–314.
Células de corteza de ratón neonatos GFAP positiva Glial fibrillary acidic protein (GFAP) is an intermediate filament and a major component of the astrocyte cytoskeleton. Enfermedad de Alexander S100 beta is a calcium-binding protein involved in the regulation of cell cycle progression and differentiation. Glutamate Aspartate trasporter Excitatory amino acid transpoter 2 Aldehyde dehydrogenase 1
Filamentos intermedios
Orígen embriológico de las microglias
Algunas funciones de las microglias durante el desarrollo del SNC
Desarrollo corteza cerebral: edad celular Pre-placa
Neuronas & Glia The cells of the nervous system. Capítulo 4 pg. 94 Microscopía de barrido de células del hipocampo . Ventura y Harris 1999. Gallo y Chittajallu 2001. Transmisión de señales eléctricas Rol activo en el funcionamiento del cerebro Neuronas excitatorias
https://socratic.org Neuronas excitatorias e inhibitorias
Figure 1. Distinct origins of excitatory neurons and inhibitory interneurons in the developing mouse neocortex Wiley Interdiscip Rev Dev Biol. 2013 Jul;2(4):443-59. hippocampus Anterior entopeduncular area Medial ganglionic eminence neocortex lateral pallium lateral ganglionic eminence preoptic area .
Eminencia ganglionar Front. Cell . Neurosci ., 30 January 2015 medial (MGE) and lateral gangionic eminence (LGE)
Meninges
Desarrollo de las Meninges
Dasgupta K, Jeong J. Developmental biology of the meninges. Genesis. 2019
Derivadas de la cresta neural Vaina de neurilema Mielinización