17. SEBORRHEIC DERMATITIS.ppt slide share

Dermatology

1. SEBORRHEIC DERMATITIS
Dr. Owen Ngalamika
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2. •Seborrheic dermatitis is a chronic,
superficial, inflammatory disease with a
predilection for the scalp, eyebrows,
eyelids, nasolabial creases, lips, ears,
sternal area, axillae, submammary folds,
umbilicus, groins, and gluteal crease
•It is characterized by scaling on an
erythematous base
•The scaling often has a yellow, greasy
appearance
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3. •It may be accompanied by severe itching
•In extreme cases the entire scalp is
covered by a greasy, dirty crust with an
offensive odor
•In infants, yellow or brown scaling lesions
on the scalp, with accumulated adherent
epithelial debris, are called cradle cap
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4. •Erythema and scaling are often seen in
the eyebrows
•In the nasolabial creases and on the alae
nasi, there may be yellowish or reddish-
yellow scaling macules, sometimes with
fissures
•It can also affect the ears and may be
mistaken for an infectious otitis externa
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5. •The postauricular region and skin under
the lobe may be involved
•The presternal area is a favoured site on
the trunk
•Seborrheic dermatitis is common in the
groin and gluteal crease, where it may
closely resemble tinea cruris or
candidiasis
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6. •The lesions of seborrheic dermatitis may
also become generalized and progress to
a generalized exfoliative erythroderma,
especially in infants with
immunosuppression
•In adults, generalized eruptions may be
accompanied by adenopathy and may
simulate mycosis fungoides or psoriatic
erythroderma
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7. •Patients with AIDS have an increased
incidence of seborrheic dermatitis
•It may also be found in obese persons with
diabetes mellitus
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11. Etiology and pathogenesis
•The yeast pityrosporum ovale has been
associated with this disorder
•The density of the yeast has been
correlated with the severity of the disease,
and reduction of the yeast occurs with
response to therapy
•P. ovale may also be abundant on the
scalps of patients without clinical signs of
the disease, and the yeast may only be
pathogenic in predisposed individuals
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12. •Patients with seborrheic dermatitis may
show upregulation of pro-inflammatory
cytokines (IF-gamma, IL-6, IL-1, IL-4)
•Recruitment of NK cells has also been
noted
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13. Differential diagnosis
•Psoriasis
•Impetigo
•Tinea capitis
•Mycosis fungoides
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14. treatment
•Topical corticosteroids
•Topical calcineurin inhibitors
•Topical antifungals (ketoconazole cream)
•Oral itraconazole and oral terbinafine
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15. End
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