2 lipid oxidation.and its various pathways

lipid oxidation is important biochemical pathways that are present in human bodies and have clinical implications

3. Triacylglycerol
Fatty acids
Acetyl CoA
TCA
CO2
Overview of lipid
metabolism

4. »Fatty acids are stored as Triacylglycerol
»Constitute 84% of stored energy
+Protein - 15%
+Carbohydrate (glucose or glycogen) - <1%
»Fatty acids mobilized from Triacylglycerol are
oxidized to meet the energy needs of a cell

6. Mobilization of FA from TG into tissues

7. (Adrenalin, Glucagon, ACTH)
Mobilization
of FA from
TG into
tissues

8. Mobilization of FA
from TG into
tissues

9. 9

11. Long assay

14. Occurs in outer mitochondrial membrane for long
chain fatty acids
Fatty Acid Acyl-CoA

15. CAT-I
CAT-II

16. Overall process of β-oxidation
7 Cycles of β –oxidation with
Successive removal of
2 carbon units
Palmitoyl-CoA

18. oxidation
oxidation
hydration
thiolysis
C
16
7 rounds
Acetyl-CoA

19. ENERGETICS OF COMPLETE OXIDATION OF PALMITIC ACID
Oxidation 7 cycles
7 FADH
2 x 2ATP/FADH
2 14 (10.5)
7 NADH + H
+
x 3ATP/NADH 21 (17.5)
From 8 acetyl CoA
Each acetyl CoA provides 12 ATP by TCA cycle96 (80)
Total ATP produced from one palmitic acid 131 (108)
Total ATP used for activation 2
NET YIELD OF ATP 129 (106)

25. β-OXIDATION
OF ODD CHAIN
FATTY ACIDS
D
L

30. It is a minor pathway
Takes place in microsomes
Involves oxidation of last
carbon atom ( ω carbon)
More common with
medium chain fatty acids