24.antiplatelet drugs

antiplatelet drugs

1. Antiplatelet drugs

Interfere with platelet
function

2. Classification
1.TXA
2
synthesis inhibitor: Aspirin
2.Others: Dipyridamole, clopidogrel, ticlopidine
abciximab

3. ASPIRIN
 Low dose aspirin (75-150 mg/day)-
selectively produce antiplatelet activity
Irreversibly inhibits thromboxane synthase
Reduces TXA
2
production  antiplatelet
activity

4. Mechanism of action
Membrane phospholipids
↓
Arachidonic acid

↓
cyclic endoperoxides
↓ Thromboxane synthase
TXA
2
(platelet aggregation)

Aspirin
Inhibits

5. Therapeutic uses
1. Myocardial infarction (MI)
2. Prevent MI in high risk patients
3. Reduce incidence of stroke in high
risk patients