46-AMMAR MUAHMMAD.pptx pharmacology. Chap

Pharmacology

1. DIURETICS AMMAR MUHAMMAD 202219210902046

2. Diuretics are medications that increase the amount of urine excreted. In order to keep the osmotic balance, water is passively transported into the urine together with Na+ and other ions Diuretics thereby increase the amount of urine produced and alter its pH as well as the ionic content of both the urine and the blood.

3. Diuretics are medicines that help reduce fluid buildup in the body. They are sometimes called water pills. Most diuretics help the kidneys remove salt and water through the urine. WHAT ARE DIURETICS DO?

4. THIAZIDE DIURETICS LOOP DIURETICS POTASSIUM-SPARING DIURETICS CARBONIC ANHYDRASE INHIBITORS OSMOTIC DIURETICS CLASSIFICATION

5. Thiazide diuretics are an FDA-approved class of drugs that inhibit the re-absorption of 3% to 5% of luminal sodium in the distal convoluted tubule of the nephron . Examples include metolazone , chlorthalidone , and indapamide . THIAZIDE DIURETICS

6. Chloro T hiazide DIURIL, SODIUM DIURIL Chlorthalidone HYGROTON Hydrochlorothiazide (HCTZ) MICROZIDE Indapamide LoZOL METALAZONE ZAROXOLYHN THIAZIDE DIURETICS

7. Loop diuretics are diuretics that act on the Na-K- Cl co-transporter along the thick ascending limb of the loop of Henle in Nephrons of the kidneys. Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule LOOP DIURETICS

8. There are few of the drug classes of loop diuretics

9. Clinical use of loop diuretics: Heart failure Edema Cerebral edema Pulmonary Edema Hypertension