7. neuromuscular blocking drugs

neuromuscular blocking drugs

1. Skeletal
muscle
relaxants

2. Skeletal muscle relaxants
Centrally actingPeripherally acting
Neuromuscular
Blocking drugs
Directly acting
drugs

3. Succinylcholine
D-tubocurarine
Vecuronium
Rocuronium
Pancuronium
Doxacurium
Atracurium
Depolarizing
Blockers
Nondepolarizing/
Competitive
Blockers
Neuromuscular
blockers
Directly acting
Dantrolene
Quinine
Centrally acting
Diazepam, Baclofen,
Tizanidine, Chlorzoxazone,
Mephensin

4. Uses of centrally acting SMRs
•Acute muscle spasm - Sprain, ligament tear,
dislocation
•Backache, torticollis, neuralgias
•Tetanus
•Spastic neurological diseases -
cerebral palsy, multiple sclerosis, spinal injuries
•Electroconvulsive therapy
•Orthopedic manipulations
•Anxiety and tension

5. Adverse effects of centrally acting SMRs
•Drowsiness
•Mental confusion
•Hallucinations
•Ataxia
•Weakness
•Night-time insomnia

6. Therapeutic uses of peripherally acting SMRs
•Adjuvant to general anaesthesia – abdominal and
thoracic surgery
•Orthopedic manipulations
•Endotracheal intubation and endoscopies
(laryngoscopy, bronchoscopy etc.)
•Convulsions and trauma from electroconvulsive
therapy
•Assisted ventilation
•Severe cases of tetanus and status epilepticus
•Malignant hyperthermia, cerebral palsy, multiple
sclerosis, hemiplegia, paraplegia - dantrolene

7. Therapeutic uses of peripherally acting SMRs
•Adjuvant to general anaesthesia – abdominal and
thoracic surgery
•Orthopedic manipulations
•Endotracheal intubation and endoscopies
(laryngoscopy, bronchoscopy etc.)
•Convulsions and trauma from electroconvulsive
therapy
•Assisted ventilation
•Severe cases of tetanus and status epilepticus
•Malignant hyperthermia, cerebral palsy, multiple
sclerosis, hemiplegia, paraplegia - dantrolene