Abo incompatibility

abo incompatibility in newborn

1. ABO INCOMPATIBILITY

2. ABO incompatibility is a part of HDN (Hemolytic Disease of Newborn). HDN also includes Rh – incompatibility.

3. Destruction of the RBCs of the fetus or newborn by antibodies produced by the mother Only IgG antibodies are involved because it can cross the placenta. HDN + F etal RBC = d e st r uction 3 Mother’s antibo d i e s

4.  fetal RBC +Maternal IgG Hemolysis of fetal RBC Anemia Accelar ared ery t hropoes i s unco n jugated bilirubinemia Jaundice after birth co n ge s tive cardiac failure Kernicterus Hydrops foetalis still birth pat hop h ysiology 4

5. Most common form of blood group incompatibility. Results from IgG anti A and anti B and commonly occurs in A and B group babies born to O group mothers. Mild and requires no treatment. ABO HDN 6

6. Test in the mother- ABO and Rh D grouping. Estimation of IgG anti A and antiB in maternal serum. ADCC(antibody dependent cell mediated cytotoxicity) test in relation to severity. INVESTIGATIONS IN ABO HDN Test in infants ABO and Rh typing. DCT Serum bilirubin level( ↑ ) - TCB Haematological parameters Reticulocytosis(5%).

7. CLINICAL DETECTION OF ICTERUS

8. Phototherapy . Exchange transfusion. Whole blood – leukocyte depleted MANAGEMENT OF ABO HDN 10

9. HOW TO PLOT ON GRAPH - Convert TSB – mg/dl to mmol by multiplying with 17.1 Convert TSB – mmol to mg/dl y dividing with 17.1

10. EXERCISE 38weeks – DOB:01/01/2019(7AM) ,TSB on 05/01/2019(7PM) is 18mg/ dl,mother Opositive,baby :B positive.Plot on graph.tell threshold limits for PT and ET. 34weeks – DOB:15/02/2019(9PM),TSB on 17/02/2019(7AM) is 14mg/ dl.Mother O+,baby:A + Plot on graph.Tell treshold limits for PT and ET

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