Absorption of drugs amit gangwal

One of the most concise PPTs on absorption of drugs.

1. Absorption of drugs
(Highly relevant and laconic information)
Dr. Amit Gangwal
AKA
AmitRatn Gangwal Jain
Associate Professor,
Smriti college of pharmaceutical education,
Indore, MP, India
Available on slideshare from June 3, 2014/4:20pm
http://www.slideshare.net/amitratn/edit_my_uploads

2. Mainly unionized drugs are
absorbed from body at
physiological conditions.

3. Ionized chemicals /drugs are
poorly absorbed from body.
They are charged, so it is
difficult for body membranes to
make them pass through so easily.

4. Ionized drugs may pass through
the cells, through pores but it will
be in poor quantity, provided they
are of low molecular weight.

5. If a drug is soluble in acidic milieu
of stomach, then it will be absorbed
from stomach, as in this
environment , this drug will be
unionized.

6. If a drug is soluble in basic
milieu of intestine, then it will be
absorbed cardinally from
intestine, as in this environment,
this drug will be unionized.

7. pKa is that ph on which a drug
is 50 % ionized.
E.g. if a drug has pKa 3.5, it
means at pH 3.5 it is 50%
ionized and 50% unionized.

8. T
hanks
With inputs from my colleagues
Mr. Avnish Jain and Ms. Payal Jain