Abzymes

Immunology

1. ABZYMES

2. •Abzymes are catalytic antibodies - Ab with
enzymatic activity
Sources of Abzymes
–Abzymes are usually artificial constructs.
–They also obtained from human and animal serum.
–Found in normal humans and inpatients with
autoimmune diseases.
–These are capable of hydrolyzing proteins, DNA, RNA,
polysaccharides etc

3. Protabzymes and DNA Abzymes
•Natural abzymes with proteolytic activity are called
Protabzymes .e.g.: hydrolysis of specific proteins in
patients with autoimmune diseases such as
bronchial Asthma ,multiple sclerosis.
•DNA hydrolyzing activity are called DNA abzymes.
•The pathogenic role of DNA abzymes is not quite
clear. However they act as a powerful regulator of
apoptosis.

4. Reactions catalyzed by Abzymes
1.Amide hydrolysis
2.Trans- Esterification
3.photo cleavage
4.Photodimerization
5.Decarboxylation
6.Oxidation
7.Cyclization
8.Reduction of diketone
9.Hydrolysis of enol ethers

5. Applications
•Synthesis of simple organic molecules
•Drug development
•Treat Cancer
•Treat allergy
• treat viral and bacterial infection

6. THANK YOU

7. THANK YOU