Access to memory cells

1. Access to memory cells Eman abd elraouf ahmed Immunology department

2. The content Innate and adaptive immune system Memory cells

3. Comparison:

4. Myeloid and lymphoid

5. Innate and adaptive

6. Innate and adaptive immune system

7. Innate and adaptive immune system

8. Innate and adaptive immune system

9. Mechanism of innate and adaptive immune cells

10. cytokines

11. Cytokines:

12. Immune response

13. Memory cell

14. Defination:memory cells Immunological memory is one of the features that define the adaptive immune response: by generating specific memory cells after infection or vaccination, the host provides itself with a set of cells and molecules that can prevent future infections and disease. the critical role CD4 T cells play in all adaptive primary immune responses

15. comparison

16. Comment figure 1 Comparison of naïve and memory CD4 T cells. Naïve T cells require signals from interleukin (IL)-7 and major histocompatibility complex (MHC) class II molecules to survive. Activation of naïve T cells occurs following interactions with antigen (Ag)-loaded dendritic cells (DCs) that express costimulatory molecules at a high level. Memory CD4 T cells receive survival signals both from IL-7 and IL-15 and there may be a role for MHC II. Activation can occur in the presence of lower levels of peptide–MHC and costimulatory signals. Following activation, memory cells proliferate less than primary responding cells but can produce a greater effector response.

17. http:// www.nature.com/icb/journal/v86/n4/fig_tab/icb200816f1.html

18. Pathway of memory cells

19. Memory-B cell

20. References: http://www.bowdish.ca/lab/current-projects/discovering-age-associated-changes-in-innate-immunity-that-correlate-with-susceptibility-to-infection/ http:// sepa.duq.edu/movies/ocos.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855788 /