Acetate mevalonate pathway

Acetate mevalonate pathway

1. GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY TOPIC: ACETATE MEVALONATE PATHWAY AND DIFFERENT SECONDARY METABOLITES OBTAINED FROM IT 5th semester, Section- B Presented by: Souvik Dutta (18601919067) Kaenat Faiz (18601919068) Kirtisha Chowdhury (18601919069)

2. CONTENT INTRODUCTION ACETATE MEVALONATE PATHWAY SECONDARY METABOLITES OBTAINED FROM THE PATHWAY CAROTENOIDS PHARMACOLOGY AND DISEASE CONCLUSION REFERENCE

3. INTRODUCTION [1] Metabolic pathway for secondary metabolites production. Biosynthetic pathway for isoprenoid derivative. Acetyl CoA is the precursor of this pathway. Mevalonic acid is major intermediate of this pathway. Terpenoids and steroids can be formed with the help of this pathway.

4. ACETATE MEVALONATE PATHWAY [1,2] Hydroxymethylglutarate- CoA Mevalonate 2NADPH 5-Phosphomevalonate ATP 5- Pyrophosphomevalonate ATP ATP -CO 2 Isopentenyl pyrophosphat e Dimethylallyl pyrophosphate Geranyl pyrophosphate Farnesyl pyrophosphate + Isopentenyl pyrophosphate

5. SECONDARY METABOLITES OBTAINED FROM THE INTERMEDIATE PRODUCTS OF ACETATE MEVALONATE PATHWAY [2] C 10 PP Geranyl Pyrophosphate C 15 PP Farnesnyl Pyrophosphate C 20 PP C 30 PP Squalene Triterpenes Steroids ×2 Phytol Gibberelin Carotenoids Gutta ×2 Isopentenyl Pyrophosphate (many addition) I sopentenyl pyrophosphate I sopentenyl pyrophosphate Monoterpenes (C 10 ) Sesquiterpenes (C 15 )

6. 2 1 Click here to add to the title CAROTENOIDS [1] C40 compound, tetraterpenoids Lipid soluble, polyene pigment Classification of caratenoid on the basis of source: Phytocaratenoids Zoocaratenoids Classification of caratenoid chemically: Carotene Carotenoid

7. PHARMACOLOGY [1] Drugs that target mevalonate pathway 1.Statins 2.Biophosphates DISEASES [1] 1.Mevalonate kinase deficiency a.Mevalonic acidura b.HIDS

8. CONCLUSION [1,2] Acetate mevalonate patway is the basic metabolism pathway which is useful for the biosynthesis of various secondary metabolites like hemiterpenes, sesquiterpenes, caratenois, squalene, steroids, etc. The mevalonate pathway begins with acetyle-CoA and ends with the production of Isopentenyl pyrophosphate (IPP)and Dimethylally pyrophosphate (DMAPP) which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholerestrol , Vitamin K, and all steroid hormones.

9. REFERENCE 1. Dr. Shukla P, Dr. Alok S, Dr. Shukla P, Pharmacognosy and Phytochemistry Semester-5, Nirali Prakashan, New Delhi. Page no.-1.8-1.9, 10.1-10.3 2. Shah B.N., Seth A.K. Textbook of Pharmacognosy and Phytochemistry. 1st ed. New Delhi : Elsevier India Pvt. Ltd; 2010. Page no.146-147

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