ADCVANCE NOVEL MANAGEMENT TREATMENT OF PCOS

Advance Novel Management Treatment Of PCOS

1. DR.D.Y.PATIL COLLEGE OF PHARMACY AKURDI SUBJECT NAME – SEMINAR/ASSIGNMENT PRESENTED BY – DHANASHRI PRAKASH SONAVANE GUIDED BY- DR. ASHISH. V. KULKARNI ROLL NO - 03 PCOD 1

2. RECENT ADVANCES IN THE MANAGEMENT OF POLYCYSTIC OVARY SYNDROME

3. Definition Introduction Cause Symptoms Diagnosis Treatment Recent advance in management of PCOS CONTENT :

4. PCOS is a hormonal imbalance due to the overproduction of androgens in ovaries PCOS is a metabolic disorder that is more severe than PCOD. In this condition, the ovaries produce a higher quantity of the male hormone and this leads to the formation of more than ten follicular cysts in the ovary every month. This stops the release of the egg leading to an ovulation. Symptoms include hair loss, obesity and infertility. PCOD is hormonal imbalance due to overproduction of immature eggs in ovaries. They, eventually, turn into cysts. Junk food, being overweight, stress and hormonal disturbances give birth to this condition.   Common symptoms of PCOD are  irregular periods , abdominal weight gain, infertility and male pattern hair loss. The ovaries usually become enlarged in this problem and secrete large amounts of androgens that cause havoc with the woman’s fertility and her body. DEFINATION PCOS PCOD

5. Globally 8% to 13% deal with PCOS with up to 70% of the impacted female population remaining undiagnosed. In India alone, 10% of the female population deal with endocrine disease. An estimated one in five (20%) Indian women suffer from PCOS. Polycystic Ovary Syndrome(PCOS) is one the most complex endocrine disease in women of child bearing age & has cascading effect on reproductive health. PCOS is characterized by underactive estrogen metabolism, ovulation disorders & polycystic ovarian changes. Besides impacting reproductive health, PCOS increases risk of metabolic diseases such as obesity, type 2 diabetes, cardiovascular diseases & hypertension. PCOS affected females are 3 times more likely to experience anxiety & depression as compared to their health counterparts. INTRODUCTION:

6. The exact cause of PCOS is unknown . There’s evidence that genetics play a role. Several other factors, most importantly obesity, also play a role in causing PCOS: Higher levels of male hormones called androgen s :  High androgen levels prevent your ovaries from releasing eggs, which causes irregular menstrual cycles. Insulin resistance:  Ana increase in  insulin   levels causes your ovaries to make and release male hormones (androgens). Increased male hormones suppress ovulation and contribute to other symptoms of PCOS.  Low - grade inflammation:  People with PCOS tend to have chronic low-grade inflammation. Your healthcare provider can perform blood tests that measure levels of  C-reactive protein   (CRP) and white blood cells, which can indicate the level of inflammation in your body. CAUSED BY :

7. SYMPTOMS:

8. A. Radiology Pelvic Ultrasonography Urine human chorionic gonadotropin level  Testosterone (free) levels  Dehydroepiandrosterone sulfate (DHEAS) and androstenedione Fasting insulin , Serum Prolactin , Serum TSH B. Blood Sugar & Lipid Level Test Fasting glucose Total, HDL, and LDL cholesterol levels as well as triglyceride levels C. Biopsy Endometrial biopsy  DIAGNOSIS

9. There is no cure for PCOS, but treatments can improve symptoms. People who have irregular periods, trouble getting pregnant or excessive acne and hair growth should speak to a healthcare professional. Some symptoms of PCOS can be reduced through lifestyle changes . Take a balanced and wholesome diet . Do regular yoga and exercise can help reduce weight and reduce the risk of type 2 diabetes .  Birth control medicines (contraceptive pill) can help regulate the menstrual cycle and reduce symptoms. Other medicines can reduce acne or unwanted hair growth caused by PCOS.  Treatments for infertility due to PCOS include lifestyle changes, medicines or surgery to stimulate regular ovulation. In-vitro fertilization (IVF ) may be used but it has some risks. Take enough sleep of at least 8 hours every day Avoid eating junk food, smoking, and drinking. TREATMENT

10. NOVEL TREATMENT FOR MANAGEMENT PCOD

11. PCOS is a complex hormonal, metabolic, and psychological disorder with numerous clinical presentations. It is one of the most common reasons for infertility. Before contemplating any pharmaceutical options, lifestyle changes should be considered the primary therapeutic prescription for PCOS-related infertility.  Ovulation stimulation, which is best performed with letrozole, is the next phase, followed by CC. Gonadotropins were the next step for women who had failed first-line oral ovulatory medication. Pregnant women who do not use ovulation stimulants or who are experiencing other infertility issues may benefit from ART. Metformin in combination with CC or gonadotropin and as an adjuvant to IVF ICSI remains the best option for people with RI or hyperinsulinemia CONCLUSION:

12. Benjamin, Jiby Jolly, et al. "Stress and polycystic ovarian syndrome-a case control study among Indian women."  Clinical Epidemiology and Global Health  22 (2023): 101326. Rocha, Ana L., et al. "Recent advances in the understanding and management of polycystic ovary syndrome."  F1000Research  8 (2019). https://www.thehindu.com/sci-tech/health/one-in-five-indian-women-suffers-from-pcos/article29513588.ece https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/novel-scientific-way-to-deal-with-polycystic-syndrome/articleshowprint/104555823.cms https://www.medindia.net/health/conditions/polycystic-ovarian-syndrome-diagnosis.htm https://www.google.com/url?sa=i&url=https%3A%2F%2Faskpinkypromise.com%2Ffaq%2Fpolycystic-ovaries%2Fwhat-is-the-difference-between-pcos-and-pcod%2F&psig=AOvVaw3GfSeIC03wJMd9tiRh8Cuv&ust=1714992002544000&source=images&cd=vfe&opi=89978449&ved=0CBQQjhxqFwoTCLjdqJup9oUDFQAAAAAdAAAAABAJ REFERENCES:

13. Thank you