Adrenergic receptors

Adrenoceptors are membrane bound receptors located throughout the body on neuronal and non-neuronal tissues where they mediate a diverse range of responses to the endogenous catecholamines- noradrenaline and adrenaline.
They are G protein coupled receptors.
Binding of catecholamine to the receptor is responsible for fight or flight response.

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2. 2 PHARMACOLOGY OF RECEPTORS- ADRENERGIC RECEPTORS PRESENTED BY- AMEENA MEHABOOB

3. INTRODUCTION Adrenoceptors are membrane bound receptors located throughout the body on neuronal and non-neuronal tissues where they mediate a diverse range of responses to the endogenous catecholamines - noradrenaline and adrenaline. They are G protein coupled receptors. Binding of catecholamine to the receptor is responsible for fight or flight response. 3

4. CLASSIFICATION 4

5. 5 RECEPTOR NAME TYPICAL LOCATIONS α 1 Vascular smooth muscle, visceral smooth muscle, radial smooth muscle of iris, CNS neurons α 2 Some presynaptic terminals, pancreatic islets, platelets, ciliary epithelium, smooth muscles, CNS neurons β 1 Myocardium, JG cells, some presynaptic terminals, CNS neurons β 2 Visceral smooth muscle, vascular smooth muscle, liver, myocardium, skeletal muscle, some presynaptic terminals, CNS neurons

6. 1. α ADRENERGIC RECEPTOR A) α 1 ADRENERGIC RECEPTOR (G q ) 6

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9. B) α 2 ADRENERGIC RECEPTOR (G i ) 9

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13. 2. β ADRENERGIC RECEPTORS A) β1 ADRENERGIC RECEPTOR (G s ) 13

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15. B) β2 ADRENERGIC RECEPTORS- 15

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17. C) β3 ADRENERGIC RECEPTORS- They are involved in the epinephrine and norepinephrine induced activation of adenylyl cyclase through the action of the G proteins of the type G s . 17

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20. REFERENCES 20 Adrenoceptor Pharmacology, Emma Robinson and Alan Hudson, Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University of Bristol. www.cvpharmacology.com/vasodilator/alpha www.ncbi.nih.gov/pubmed/6098436 www.wikipedia.com

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