In most instances patients will remain asymptomatic or
minimally symptomatic following the initial decline in
pumping capacity of the heart.
compensatory mechanisms become activated and appear to
modulate LV function within a physiological/homeostatic
range, such that the functional capacity of the patient is
preserved or is depressed only minimally.
The compensatory mechanisms that have been described
1.Activation of the adrenergic nervous systemic
2.Activation of the RAAS
3.Activation of inflammatory mediators: that are
responsible for cardiac repair and remodeling
Both are responsible for maintaining CO through increased
retention of salt and water, peripheral arterial
vasoconstriction and increased contractility