Air Handling Systems Air Handling Systems Air Handling Systems Air Handling Systems

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1. Air Handling Systems

Heating
Ventilation and
Air Conditioning (HVAC)
Part 2: Components
Supplementary Training Modules
on GMP
Module 3, Part 2: Components Slide 1 of 20 WHO - EDM

2. Module 3, Part 2: Components Slide 2 of 20 WHO - EDM
Air Handling Systems
Purpose of an air handling system
Air Handling
System
Production Room
With
Defined
Requirements
Supply
Air
Outlet
Air

3. Module 3, Part 2: Components Slide 3 of 20 WHO - EDM
Air Handling Systems
Objectives
In the following slides, we will study the components of air
handling systems in order to:

1. become familiar with the components
2. know their functions
3. become aware of possible problems

4. Module 3, Part 2: Components Slide 4 of 20 WHO - EDM
Air Handling Systems
+
Production Room
Exhaust air treatment
Central air handling unit
Terminal air treatment
at production room level
Fresh air treatment
(make-up air)
Main subsystems

5. Module 3, Part 2: Components Slide 5 of 20 WHO - EDM
Air Handling Systems
FilterSilencer
Terminal filter
Weather louvre
Control damper
FanFlow rate controller
Humidifier
Heating
coil
Cooling coil
with droplet
separator
Production Room
Overview components
+
Prefilter
Exhaust Air Grille
Heater
Secondary Filter
Re-circulated air

6. Module 3, Part 2: Components Slide 6 of 20 WHO - EDM
Air Handling Systems
Weather louvre
Silencer
Flow rate controller
Control damper
To prevent insects, leaves, dirt and
rain from entering
To reduce noise caused by air
circulation
Automated adjustment of volume of
air (night and day, pressure control)
Fixed adjustment of volume of air
Components (1)

7. Module 3, Part 2: Components Slide 7 of 20 WHO - EDM
Air Handling Systems
Heating unit

Cooling unit
/dehumidifier

Humidifier

Filters
Ducts
To heat the air to the proper temperature
To cool the air to the required temperature
or to remove moisture from the air
To bring the air to the proper humidity, if
too low
To eliminate particles of pre-determined
dimensions and/or micro-organisms
To transport the air
Components (2)

8. Module 3, Part 2: Components Slide 8 of 20 WHO - EDM
Air Handling Systems
Flow rate controller
Control damper
Humidifier
Cooling battery
Filters
Ducts
Blocked
Poorly adjusted, bad pressure differential system
Bad water/steam quality/poor drainage
No elimination of condensed water/poor drainage
Incorrect retention rate/damaged/badly installed
Inappropriate material/internal insulator
leaking
Problems with components

9. Module 3, Part 2: Components Slide 9 of 20 WHO - EDM
Air Handling Systems
+
Production Room
Exhaust
air
Return air
(re-circulated)
Fresh air
(make-up air)
Supply
air
Air types

10. Module 3, Part 2: Components Slide 10 of 20 WHO - EDM
Air Handling SystemsParticles / m
3
 0.5µm
US 209D
non-
metric
US 209E
1992
metric
EC cGMP
Annex I
1997
Germany
VDI 2083
1990
UK
BS 5295
1989
Japan
JIS B 9920
1989
ISO 14644-
1
1
3,5 0 2 2
10 M 1
35 1 M 1.5 1 3 3
100 M 2
353 10 M 2.5 2 4 4
1.000 M 3
3.530 100 M 3.5 A, B
A= unidirectional
B= turbulent
3 E or F 5 5
10.000 M 4
35.300 1.000 M 4.5 4 G or H 6 6
100.000 M 5
353.00010.000M 5.5 C 5 J 7 7
1.000.000 M 6
3.530.000100.000M 6.5 D 6 K 8 8
10.000.000 M 7
Comparing International Cleanroom Classifications

11. Module 3, Part 2: Components Slide 11 of 20 WHO - EDM
Air Handling Systems
Filter classes
Dust filters
Standard Aerosol
FineCoarse ULPAHEPA
10 µ m > Dp > 1 µ mDp > 10 µ m Dp < 1 µ m
F5 - F9G1 - G4 U 14- 17H 11 - 13
EN 1822 StandardEN 779 Standard

12. Module 3, Part 2: Components Slide 12 of 20 WHO - EDM
Air Handling SystemsAverage Efficiency
Integral Value
Peak Arrestance
Local Value
Retention in
%
PenetrationEfficiencyPenetration
F9 85 0.15
H11 95 0.05
H12 99.5 5x10
-3
97.5 25x10
-3
H13 99.95 5x10
-4
99.75 25x10
-4
U14 99.995 5x10
-5
99.975 25x10
-5
Classification of filters according to their efficiency

13. Module 3, Part 2: Components Slide 13 of 20 WHO - EDM
Air Handling Systems
Primary panel filter
Secondary filter
HEPA or tertiaary filter

14. Module 3, Part 2: Components Slide 14 of 20 WHO - EDM
Air Handling Systems
Humidifier Silencer Heating and
cooling units

15. Module 3, Part 2: Components Slide 15 of 20 WHO - EDM
Air Handling Systems
Control damper for air flow
De-humidification
Filter Pressure
Gauges
AHU with fan Variable
Speed Controller
Humid room air
Air heater
Regeneration air
Humid room air
Adsorber wheel
Dry air
Air handling unit

16. Module 3, Part 2: Components Slide 16 of 20 WHO - EDM
Air Handling Systems
Swirl Type air diffusors with
terminal filters
1 Filter
2 Tightening frame
3 Register outlet
4 Screw fixation for register
1
2
3
4

17. Module 3, Part 2: Components Slide 17 of 20 WHO - EDM
Air Handling Systems
Low induction
swirl diffusor
(preferred)
High induction
office type diffusor
(avoid)

18. Module 3, Part 2: Components Slide 18 of 20 WHO - EDM
Air Handling Systems
Annex 1, 17.26
Regulation of room pressure – pressure differentials concept
Room pressure
gauges
Room pressure indication panel

19. Module 3, Part 2: Components Slide 19 of 20 WHO - EDM
Air Handling Systems
Pressure cascade injectables
Protection from micro-organisms and particlesNote : Direction of door opening relative to room pressure
15 Pa
0 Pa
Air
Lock
30 Pa PassageD
C
A
B
D
LF
Air LockAir Lock
45 Pa
Room 3 Room 2 Room 1
45 Pa60 Pa30 Pa
Annex 1, 17.24, 17.25

20. Module 3, Part 2: Components Slide 20 of 20 WHO - EDM
Air Handling Systems
Pressure cascade solids
Protection from cross-contaminationNote : Direction of door opening relative to room pressure
15 Pa
15 Pa15 Pa
E
30 Pa
Passage
0 Pa
Air
Lock
Room 3 Room 2 Room 1
15 Pa
Air LockAir Lock