AKT/PKB SIGNALING PATHWAY

This pathway tells about cell survival and growth

1. AKT/PKB SIGNALING PATHWAY Presented By P. Veeresh NIPER A1719PC07 M.S. Dept. of Pharmacology & Toxicology National Institute of Pharmaceutical Education & research, Ahmedabad.

2. Intracellular signal transduction pathway that promotes Metabolism Proliferation Cell survival Key proteins: AKT/PKB & PI3K AKT/PKB was discovered as a proto oncogene in virus termed ATK8, then later isolated and named AKT PIP3k an enzyme had been isolated in 1990 by group of cantley

3. pathway Protein synthesis Cell survival Cell proliferation Glucose metabolism

4. PROTEIN SYNTHESIS AKT TSC1 TSC2 mTORC1 PROTEIN SYNTHESIS

5. CELL SURVIVAL BAD CAS9 IKK YAP Mdm2 CREB NFkB P73 Bcl2, pro survival genes Bax P53 Bcl2 Bcl xl AKT Direct regulation of apoptosis Transcriptional control of apoptosis

6. CELL PROLIFERATION AKT CDK,s CYCLIN Cell cycle P 21 p27 GSK3

7. Glucose metabolism I AKT GSK3 GS G G Glycogen Glycolysis GLUT4 GLUT1

8. CASCADE

9. RELATIONSHIP WITH CANCER Over activation of pathway Mutations: PI3K PTEN AKT/PKB Due to the critical role of AKT/PKB in regulating diverse cellular functions it is an imp therapeutic target for the treatment of human diseases

10. AKT PATHWAY INHIBOTORS FOR TREATING CANCER