Objectives
Introduction
Origin of Alzheimer’s disease
Meaning
Incidence
Pathophysiology
Risk factors
Signs and symptoms
5 A’s of Alzheimer’s disease
Cont
Diagnostic test
Complications
Prevention’s
Treatment
Medical management
Nursing management
Introduction
Alzheimer’s disease is a neurodegenerative Brain disorder.
It is the most common form of dementia.
It usually starts in late middle age or in old age (above 65 years)
It is characterized by progressive memory loss.
Formation of neurofibrillary tangles and plaque containing beta –amyloid
cells.
Origin of Alzheimer’s Disease
The disease was first described by Dr. AloisAlzheimer a German physician,
in 1906. Alzheimer had ha patient named AugusteD , in her fifties who
suffered from what seemed to be a mental illness. But when she died in
1906, an autopsy revealed dense deposits,nowcalled neuriticplaques,
outside and around the nerve cells in her brain. Inside the cells were
twisted strands of fiber, or neurofibrillary tangles. Since Dr.AloisAlzheimer’s
was the first person who discovered the disease. AD was first named after
him.
Meaning
Alzheimer’s disease is chronic, irreversible Disease that
affects the cells of the Brain and causes impairment of
intellectual functioning.
Alzheimer’s disease is a brain disorder which gradually
destroys the ability to reason , remember, imagine and
learn.
Incidence
About 3 percent of men and women ages 65 to 74 have Alzheimer’s
disease,andnearly half of those age 85 and older may have the disease.
About 3,60,000 new cases of Alzheimer are diagnosed each year. Almost
two –third of Americans with Alzheimer’s are women.
5 A,s of Alzheimer’s disease
Anomia: can’t remember
names/things
Aproxia: Misuse of object due to
failed recognition
Agnosia: can’t recognize familiar
objects/tastes , Sound.
Amnesia: Memory loss
Aphasia: Can’t express themselves
Via speech.
Pathophysiology
Changes in the brain structure and function.
Amyloid palque
Neurofibrillary tangles
Loss of connection between neurons
Neurons death
Plaque develop first in areas of the brain used for memory and cognitive
function including hippocampus, especially the areas responsible for
language and reasoning.
Neurofibrillary tangle
Conti…
Abnormal collection of twisted protein threads inside cells.
Risk factors
Old age
Female gender
Family history
Genetic mutation
Low socio-economic status
Obesity
Smoking and drinking
Sedentary lifestyle
Head injury
Conti…
Diabetes
Hypertension
Hypercholesterolemia
Depression
Down syndrome
Metalaindustrial or other toxins
The abnormal build-up of proteins in and around the Brain
Infection
Signs
Memory loss
Difficulty to performing familiar tasks
Problem with language
Disorientation to time and place
Pooreordecreased judgement
Problem with abstract thinking
Misplacing things
Changes in moodeorbehavior
Conti…
Changes in personality
Loss of initiative
Symptoms of AD
Confusion with time or place
Unexplained mood swings
Problem with attention and spatial orientation
Disturbance in short –term memory
Forgetfulness
Behavior changes
Difficulty swallowing
Unfounded emotions
Trouble with familiar task
Preventions of AD
Prevent and manage high BP
Manage blood sugar
Maintain a healthy weight
Be physically active Quit smoking
Avoid excessive drinking
Prevent and correct hearing loss
Get enough sleep
Health diet
Conti…
Social engagement
Proper medication
Regular exercise
Logic games
Reading of books
Mental stimulation
Regular sleep
Physical work
Medical Diagnosis
No single clinical test but a comprehensive
Evaluate may be done
Physical examination
Psychiatric assessment
Complete health history
Neurological and mental status assessment
Brain imaging test (e.gCT,MRI and SPECT)
CSF examination
Nursing interventions
Avoid harmful substances
Exercise regularly
Excessive drinking drug abuse can damage Brain cell
Use a rather low voice and spoke slowly in front of patient
Assist with ADLs as needed
Provide emotional support to the patient and his family
Establish an effective communication system with the patient and his family to
help them adjust to the patient altered cognitive abilities
Administer ordered medications and notes their affects if the patient has
trouble swallowing, crush tablets and open capsules mix them with a semi soft
food
Conti…
Protect the patient from injury by providing a safe ,structured environment
Provide rest periods between activities because the patient tires easily.
Encourage the patient to exercise as ordered to help maintain mobility.
Encourage sufficient fluid intake and adequate nutrition.
Take the patient to the bathroom at least every 2 hours and make sure he
knows the location of bathroom.
Assist the patient with hygiene dressing as necessary.
Frequently check the patient vital signs
Conti…
Monitor the patient fluid and food intake to detect imbalances
Inspect the patient skin for evidence of trauma, such as bruises or skin
breakdown
Encourage the family to allow the patient much independence as
possible while ensuring safety to the party and other.
Complications
Bedsores
Pneumonia
Dehydration and malnutrition
Wandering and restlessness sleep disturbances
Loss of control of bodily functions
Injuries due to falls
Agitation
Infection