Alzheimers disease.Symptoms and Management

Symptoms management and diagnosis of alzheimers disease is mentioned in the ppt.Description about plaques and tangles mentioned.Ayurvedic management is taken from renowned physician Dr L Mahadevan sir textbook

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3. Most common cause for Dementia INTRODUCTION It’s a neuro degenerative disease (Particularly in cortex) 3

4. PATHOLOGY Caused due to PLAQUES & TANGLES AMYLOID PRECURSOR PROTEIN Inside cell Outside cell Helps neuron grow & repair Recycles by Alpha secretase & Gamma secretase Beta secretase & Gamma secretase BETA AMYLOID PLAQUES 4

5. PATHOLOGY Disrupts signaling and Memory is impaired Immune response Causes inflammation and destroy surrounding neurons Amyloid angiopathy Weakens the wall and increases hemorrhage 5

6. PATHOLOGY Phosphate group in kinase attaches Neuro fibrillary tangles Under go programmed cell death called APOPTOSIS 6

7. Atrophy (shrinks) PATHOLOGY Gyri Become narrower Sulci Become wider Ventricles Become larger 7

8. CLASSIFICATION Sporadic Familial Sporadic Late onset (After 85 years ) Caused due to genetical and environmental factors APOE e4 gene is said to be one of the factor Familial Early onset ( 4O years ) Due to dominance of PSEN 1 & PSEN 2 GENES In trisomy 21 ( extra chromosome APP gene ) 8

9. SYMPTOMS Aggravates when plaques & tangles build up 9

10. DIAGNOSIS Definitive diagnosis – Brain biopsy during autopsy Exclude other causes of dementia (AS dementia , vascular dementia etc) TREATMENT There is no definitive cure Some medications like TACRINE,RIVASTIGMINE etc ASSESMENT ADAS Cog MMSE (Mini Mental State Examination 10

11. AYURVEDIC VIEW Smrithibhramsha Disease of mind developed due to provoked vata 11

12. NIDANA हीन सत्व रजः predominant प्रकृति Diet dominant in रजः and तमः गुण This diet depreciates धृति and there by affects the functions of mind Mind in stressful condition 12

13. SAMPRAPTHI Due to this निदान प्राण वात प्राण वात प्राण वात प्राण वात उदान वात व्यान वात Goes to हृदय Dislodges अवलम्बक कफ तर्पक कफ Impairs साधकाग्नि 13

14. SAMPRAPTHI VIGHADANA Dosa Mano Doşa : Rajas and Tamas Šaririka Doşa Vāta : Prāņa , Udana , Vyāna Pitta : Sādhaka Kapha : Tarpaka , avalambaka kapha Dūşya : Rasa, Rakta , MajjaSrotas , Manovaha , Rasavaha , Majjā vaha Agni : Manda, Visama Udbhava Sthāna : Manas Adhisthana : Sirohrdaya Vyaktisthāna : Manas, Sarva Sarira , Indriya 14

15. Pūrvarūpa : Alpa Vyakta laksana Rupa : Udvega , Smrtināsa , Kampa , Bhaya etc. Upasaya - Dhairya , Asvasana , Medhya and Rasayana dravyas Anupsaya – Klesha Arishta Lakşaņa - Sarva Sampurna Laksana and chronicity Sadhyasādhyata - Krchraasādhya / Yapya / Asādhya depending on severity and chronicity Upadrava - Can produce several psychosomatic symptoms and diseases. Rogamarga - Madhyama 15

16. CHIKITSA SIDHANTHA Vata predominating loss of memory is alzheimers disease In Alzheimers disease , Medicines that subsides vata and that enhance Memory ( Medhya oushadhas ) are useful Brain is Structurally Kapha and functionally vāta . Tikta rasa is laghu in nature. Laghu guna is helpful in its functions like thinking, imagination, creativity, etc. so without laghu guna , its function would be nil, hence tikta and Madhura rasa are given together in promoting intellect and improve its functions 16

17. CHIKITSA Eka mulika prayogam Mandukaparni kşira kaşāyam 60 ml hs after food. Yastimadhu curņam3-5 gms hs with milk after food Shankhapushpi curnam5 gms hs with milk after food Asvagandha curnam 10 gms hs with milk after food Küşmandam svarasam 50 ml bd after food Jyotismati curnam (with milk at bed time)5 gm Badam (Almond)3 to 4 nuts in empty stomach. Kashaya Kalpana Dose : 60 ml bd half an hour before food Balāmula kaşāyam Drākşādi kaşāyam Kalyāņaka kşıra kaşāyam Internal medicines 17

18. Internal medicines Churna Kalpana Asvagandha churnam 10 gms hs with milk after food Jatamāñji churnam 5 gms hs with milk after food Sarasvatha churnam -5 gms hs with honey after food Vati Kalpana Dose : 1 bd after food Purņacandrodayam Svarņamuktādi vati Svarņa bhasmam - 1 pinch bd with honey after food Lehya Kalpana Dose : 10 gms bd after food Küşmanda avaleham 18

19. Internal medicines Ghrtha Kalpana Dose : 10 ml hs with milk after food Kalyanaka ghrtham Asta dasa küşmanda ghrtham Jivanthyadi ghrtham Taila kalpana (Internal) Kşırabalā tailam -10 ml with milk after food Prasariņi tailam 5 ml hs with milk after food 19

20. External therapies Siro picu Balā lākṣādi tailam Vatāsini tailam Sirovasti Bala lakṣādi tailam Kşirabalā tailam Vatasini tailam Dhanvantaram tailam Vasti Rājayāpana vasti Nasyam Dose : 2 ml in each nostril Kşirabala tailam 20

21. YOGA 21 Padmasana Sarvangasana Bhramari Vrikshasana Shavasana Pashchimothasana Shirshasana Bhasthrika Surya namaskar

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23. REFERENCE Text Book of Medicine – KV Krishna Das Essentials of physiology – K Sembulingam Ayurvedic clinical practitioners book – Dr L Mahadevan Ashtanga hridaya - soothrasthana Susrutha samhitha - Sharirasthana 23

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