Amikacin

1. Aminoglycosides Potent bactericidal antibiotics 

2. Aminoglycosides Strong Aerobic, gram-negative and gram-positive bacterial coverage Rapid concentration-dependent killing and post-antibiotic effect  Used in the treatment of severe infections of urinary, intra-abdominal and sepsis etc. But,

3. Major limitation

4. Aminoglycoside nephrotoxicity cascade Amer J Med 1986;80:105-114

5. Antimicrob Agents Chemother 1999;43:1003-12

6. Aminoglycoside Ototoxicity cascade