Aminophylline drug

This slide include information regarding aminophylline drug.

1. AMINOPHYLLINE PREPARED BY: SONALI KOIRI BNS 1 ST YEAR ROLL NO - 20

2. At the end of presentation , participants will be known about aminophylline : 1.Introduction 2.Mechanism of action 3. Indication 4. Adverse effect 5. Contraindication 6.Nursing consideration OBJECTIVES

3. Brochodilators CLASSIFICATION

4. Aminophylline : Chemical class- xanthine Therapeutic class - bronchodilator Pregnancy category- C Introduction

5. Route Onset Peak Duration P.O. (E.R.) Unknown Unknown 8–12 hr P.O. (tab) Unknown Unknown 6–8 hr I.V. Immediate Unknown 4–8 hr Aminophylline

6. Mechanism of action

7. Phosphodiesterase inhibitor Increased cAMP concentration in bronchial smooth muscels cells Bronchodilation Mechanism of action

8. Inhibition of receptors for adenosine Bronchodilation Reduce inflammatory activity Mechanism of action

9. Asthma. COPD: to reduce the symptoms. Also used to treat apnea. INDICATION

10. GIT Nausea and vomiting Gastric upset Abdominal pain Diarrhoea CNS Headache Insomnia ADVERSE EFFECT

11. Restlessness Seizure Epilepsy RENAL Diuresis CVS Palpitations Arrhythmias Continue….

12. WARNING : Because aminophylline has a narrow therapeutic window (10 to 20 mcg/ml), closely monitor serum theophylline level and watch for evidence of toxicity tachycardia, tachypnea , nausea, vomiting, restlessness, seizures). Acetaminophen, furosemide , coffee, tea, soft drinks, and chocolate can alter serum theophylline result. NURSING CONSIDERATIONS

13. To determine peak serum theophylline level, draw blood sample 15 to 30 minutes after administering I.V. loading dose. Give immediate-release and liquid forms with food to reduce GI upset. Give E.R. form 1 hour before or 2 hours after meals because food can alter drug absorption.

14. Advise patient to avoid excessive caffeine (in coffee, tea, soft drinks, and chocolate); It can falsely elevate theophylline level. Explain that blood tests may be needed to monitor drug’s therapeutic effect. Patient teaching