An introduction to Embase

In this webinar we introduce you to the workflows supported by Embase, describe the benefits of Embase content and coverage and show you how you may utilize deep drug indexing to pinpoint and track biomedical information.

1. Embase – Answers to your biomedical questions Your presenter: Ann-Marie Roche Welcome to our Embase webinar!

2. About us

3. Webinar control panel: ‘ chat’ or ‘ask a question’ for questions and comments Option for full screen view Q&A at the end Need to know

4. With over 24 million indexed records and more than 7,600 currently indexed peer-reviewed journals, Embase is a highly versatile, multipurpose and up-to-date database covering the most important international biomedical literature from 1947 to the present day. Core strengths of Embase include coverage and in-depth indexing of the drug-related and clinical literature, with a particular focus on comprehensive indexing of adverse drug reactions; emphasis on Evidence Based Medicine (EBM) indexing including systematic reviews, and coverage and indexing of journals and articles relevant to the development and use of medical devices.  If you are searching for answers to your questions or simply need reliable, peer-reviewed information on topics such as drug development or use, toxicology, drug safety / adverse drug reactions, clinical trials, evidence based medicine, medical devices, pharmacoeconomics , preclinical reports, basic biomedical science or regulatory affairs, then Embase is the solution you are looking for. Our value story

5. Conference proceedings How Embase delivers value… 5 Very powerful Search Environment ... by including literature and information resources in a timely manner ...by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc. ... by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Scientific Journals In Press (unpublished) ...by allowing users to automate searching and result management E-mail Alerting API Interoperability Deep indexing using own taxonomy We make sure you don’t miss any biomedical literature They only close alternative is reading all the articles Good precision and recall balance Automation and documentation

6. Currency & Completeness Information that can have impact on the future of a research project, development pipeline or existing business is of high value. Getting that information complete and in time is critical. Pharma / Device (co)vigilance is driven by the need to have timely insight into potential adverse effects or new applications of a drug or device Information overload With a growing universe of scientific information, consumers have a hard time keeping up with the latest information and determining the value and reliability of that information. Evidence Based Medicine is driven by the need to cope with information overload. Dispersed Information Information resources are dispersed across different platforms, thus requiring multiple searches to be executed and build in multiple query languages. The more platforms, the more cumbersome to maintain and support. Tools that help consolidate and search comprehensive files are in demand. How do we find the most valuable information? How do you make sure we capture the most current information? How do you capture all the information effectively? Research community Business community & regulators Information professionals By doing systematic reviews to identify, appraise, select and synthesize all scientific information By setting up structural searches and alerts to monitor for drug or device mentions By trying to consolidate searching and storing on as few systems as possible How Embase delivers value…

7. Our strengths…

8. Our strengths…

9. Confidence 9

10. Emtree : Biomedical thesaurus, over 60k terms Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950- MEDLINE: 2,500 journals unique to Embase, mapped to Embase indexing, 1950- (including MEDLINE Classic) Embase Classic: Digitally scanned and re-indexed, 1947-1973 AIP and In Process: Indexing added, from 2009 Conference Abstracts: Indexing added, from 2009 1947 1950 1974 2009 Content Overview Including 5.5M not found in MEDLINE

11. Deep indexing 11

12. 60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non-Proprietary Names ( INNs ) described by WHO from 2000. Deep indexing - Emtree What is mapping ? Mapping means you retrieve the same results regardless of which term you use e.g. Type II diabetes or non insulin dependant diabetes mellitus.

13. 78 drug and disease subheadings Deep indexing - Emtree 14 study types, including NEW Diagnostic Test Accuracy Study

14. Precise Retrieval

15. Start searching… Find the best terms for your search and include synonyms automatically with autocomplete in Quick Search

16. Click on Disease Filter for example, to see which diseases are referenced with Januvia , either as a therapeutic area or side effect.

17. Conference Abstracts 17 Coverage began in 2009. http://embase.com/info/what-is-embase/coverage for the up to date list of conferences and number of abstracts covered.

18. Registering in Embase 18 Setting up email alerts Saving your searches Staying up to date

19. Embase: A Case Study

20. Case study A clinician is working on a systematic review for publication. She needs to adhere to certain guidelines to ensure she has conducted a through search of the literature. http://www.youtube.com/watch?v=QzZbYMS1tQ4 Question Are there any risks associated with the administration of antibiotics together with digoxin in a patient with congestive heart failure who has contracted pneumonia?

21. Articles like this contain vital information...

22. For example…

23. Comprehensive searching in Embase 23

24. 2 sets of results…Why are the results so different and does it matter…?

25. 23 synonyms as well as ‘antibacterial agent’ are searched simultaneously as well as over 38 narrower terms (including moxifloxacin ). No simultaneous searching of synonyms or narrower terms= Only ‘antibacterial agent’ is searched and this does not find all the vital information

26. Found in your Embase results, not in your non-indexed supported search...

27. 2 thesaurus assisted searches but different results? Embase has unique content ,such as conference abstracts.

28. Found in your Embase search, not in your MEDLINE search... We are looking for digoxin AND ‘antibacterial agent’ but Medline does NOT index digoxin in this article.

29. Poll The poll should appear on your screen shortly...

30. Let’s take a look at Embase... …by going to www.embase.com

31. Building and combining searches Use single quotes to capture a phrase ‘diabetes mellitus’ for example (not with Autocomplete in Quick Search) Break up your search into individual searches, such as a drug search (in Drug Search form) and a disease search (in Disease Search form) and combine your results in Session Results Run your cursor over your search to Edit or copy to a Search Form for guided editing. Truncation and operators, AND, OR, NOT, NEXT, NEAR Refer to http://info.embase.com/helpfiles for more guidance and links to materials such as the Quick User Guide.

32. Refining your search Quick and Advanced Limits on Advanced, Drug and Disease Search forms Major Focus on all advanced forms – major drugs and diseases retrieved Field limits under Advanced Search box to search in specific fields such as article title, abstract, conference name, drug name etc Drug and Disease Subheadings to limit to specific concepts such as Adverse Drug Reaction, Drug Comparison and Side Effect. Filters on Session Results page for specific diseases or study types for example Check out our training videos at www.trainingdesk.elsevier.com/embase for more guidance .

33. Thank you and see you next time Q&A will be sent to you by email and for more information and questions please contact [email protected] Embase webinars occur on the 04th Wednesday of every month and our next webinar Train the trainer is aimed at trainers. Go to www.trainingdesk.elsevier.com/embase for all training related materials Please fill out the survey that appears on your screen after leaving the webinar.