Angiogenesis of Cancer Cellvhhhvvvs.pptx

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1. ANGIOGENESIS OF CANCER CELLS Presented By : Ahmed Bahr Head of Oncology Journal Club ,Vice- head of ASSIA Research Team ASSIA Research Team| 2024

2. Angiogenesis, the formation of new blood vessels, is a cascade of cell signals Why angiogenesis? Tumor angiogenesis allows for supply of oxygen, nutrients, growth factors, and tumor dissemination to distant sites. ( nutrition, Proliferation, and metastasis)

3. trannscription factor the final product into the cascade in cytoplasm , then enters the nucleus to target amplification of specific gene ( amplification of transcription)

4. The most important growth Factors: 1- Vascular endothelial growth factor (VEGF) is considered a signifcant contributor to the development of tumor vascular systems, and is regulated by VEGF, a gene family that includes several VEGF variants such as VEGFA, B, C and D, alongside placental growth factor. The VEGF receptor, VEGFR, consists of three domains: an extracellular domain for VEGF binding, a transmembrane domain, and an intracellular domain with tyrosine kinase activity that recruits various downstream molecules ( a cascade of signals).

5. The dual nature of the TGF-β signaling pathway in tumor development has led to what is known as the TGF-β paradox. The TGF-β signaling pathway exerts multiple efects on tumor cells, apoptosis induction, inhibition of tumor cell proliferation, regulation of genomic instability, promotion of EMT, stimulation of neo-angiogenesis, immune damage, cell migration, and promotion of metastasis. Multiple studies have demonstrated that the TGF-β signaling pathway exerts a tumor suppressor efect on the pathogenesis of HCC.

6. What about the next session?? Reading a Paper , preferably, Literature Review Extract the main points to discuss with us Get valuable ideas to investigate if we can implement your idea and transform it into the research community Best wishes from ASSIA Research Team to all aspiring researchers