ANS (Sympathetic & Para-Sympathetic Drugs) By; Baqir Naqvi.pptx

Pharmacology of Autonomic Nervous System Drugs.

1. Drugs Acting on Para-Sympathetic Nervous System & Sympathetic Nervous System By: Dr. Baqir Raza Naqvi Autonomic Nervous System 1

2. Organization of ANS (Autonomic Nervous System) its subdivisions and innervations 2

3. Nervous system 3

4. 4

5. 5

6. 6

7. A . Somatic Nervous System 7

8. B . Autonomic Nervous System Controls and regulates normal daily vital body functions Involuntary and Consists of ; 8

9. 9

10. 10

11. 11 General comparison b/w SNS & PSNS

12. 12 General comparison b/w SNS & PSNS

13. 1 . Sympathetic N.S 13

14. 2 . Parasympathetic N.S 14

15. Functions of Parasympathetic Nervous System Functions of Sympathetic Nervous System 15

16. 16 General comparison b/w SNS & PSNS

17. 3. Enteric Nervous System 17

18. Various Neurotransmitters 18

19. 19

20. Drugs Acting on Para - Sympathetic Nervous System 20

21. Synthesis of Acetylcholine ( Neurotransmitter of Parasympathetic N.S) Choline enters the cholinergic neuron by carrier-mediated transport, where it reacts with acetyl-CoA with the help of choline acetyltransferase ( ChAT ) to form ACh . The ACh is then stored in storage vesicles. It is released into the synaptic cleft, when an action potential reaches the nerve terminals. Released ACh interacts with cholinergic receptors on effector cell and activates them . In the synaptic cleft, the ACh is rapidly hydrolyzed by acetyl cholinesterase (AChE) enzyme. 21

22. 22 Synthesis of Acetylcholine ( Neurotransmitter of Parasympathetic N.S)

23. Cholinergic Receptors in Body (Muscarinic & Nicotinic Receptors) 1. Muscarinic 23

24. 2. Nicotinic 24

25. 1.Para-Sympathomimetic Drugs 25

26. Therapeutic Uses of Cholinergic Drugs 26

27. 27

28. 2. Para-Sympatholytic Drugs Or Anti Cholinergic drugs 28

29. Therapeutic Uses of Anti- Cholinergic Drugs 29

30. 30

31. Drugs Acting on Sympathetic Nervous System 31

32. Synthesis of Catecholamine's (NA ) Neurotransmitter of Sympathetic N.S) It begins with the amino acid tyrosine, which is transported into the adrenergic neuron by active transport. In the neuronal cytosol, tyrosine is converted to DOPA by tyrosine hydroxylase and DOPA to dopamine (DA ) by DOPA decarboxylase. Dopamine enters the storage vesicles of the nerve terminal by active transport, where it is converted to NA (Norepinephrine) by the enzyme dopamine hydroxylase the NA formed gets stored in the vesicles. In the adrenal medulla, NA is further converted to adrenaline by N- methyltransferase . Small quantities of NA are released continuously into the synaptic cleft and large quantities during nerve stimulation. 32

33. 33 Synthesis of Catecholamine's (NA ) Neurotransmitter of Sympathetic N.S)

34. 34

35. Adrenergic Receptors in Body (Alpha & Beta Receptors) 35

36. 36

37. 37

38. 38 (dilation  of pupil )

39. 39

40. 1. Sympathomimetic Drugs 40

41. Sympathomimetic Drugs (Cont.) 41

42. 2. Sympatholytic Drugs 42

43. 1. 43

44. 2. 44

45. Thank you ! 45