Anti Obesity effect of fucoxanthins and allenic cartenoids.pptx

Anti Obesity effect of allenic cartenoids and fucoxanthins

1. Anti obesity effect of allenic carotenoid fucoxanthin

2. Content Carotenoids Types of carotenoids Functions and benefits Chemical structure Anti-obesity effects How flucoxanthin tackles obesity Metabolism of flucoxanthin Studies Conclusion

3. What are carotenoids ? Carotenoids are a class of natural pigments found in plants, algae, and photosynthetic bacteria. They’re responsible for the vibrant colors in fruits and vegetables, ranging from orange to red and yellow. These pigments play a crucial role in protecting cells from damage caused by free radicals and have been linked to various health benefits.

4. Types of carotenoids - Carotenes: Strictly hydrocarbons, examples include:
- α-carotene
- β-carotene
- Lycopene - Xanthophylls : Contain polar end groups, examples include:
- Lutein
- β ixin - Capsanthin

5. Functions and Benefits Antioxidant Properties: Protect cells from damage and reduce the risk of chronic diseases like cancer, cardiovascular disease, and age-related macular degeneration. - Provitamin A: Some carotenoids, like β-carotene, can be converted to vitamin A in the body, essential for healthy vision, immune function, and skin health. - Food Coloring: Carotenoids are used as natural food colorants, adding color to products like margarine, cheese, and fruit juices.

6. What Is Fucoxanthin ? Fucoxanthin , a xanthophyll carotenoid found in brown seaweeds such as wakame and kombu, has been shown to have potential anti-obesity effects. It’s known for its antiinflammatory and antioxidant properties.

7. Chemical structure Fucoxanthin and beta-carotene, both carotenoids, share a similar basic structure of a polyene chain with conjugated double bonds. However, fucoxanthin distinguishes itself with an unusual alleneic bond and a hydroxyl group, whereas beta-carotene lacks these features. The alleneic bond in fucoxanthin is a double bond between two adjacent carbon-carbon double bonds, and the hydroxyl group is an oxygen-hydrogen bond. An allenic bond: Two adjacent carbon-carbon double bonds. A 5,6-epoxide group: An oxygen atom bridging two carbon atoms. Conjugated carbonyl group: A carbon-oxygen double bond. Multiple hydroxyl groups: Oxygen-hydrogen bonds. Polyene chain: A series of conjugated double bonds.

8. Anti – obesity Effects Research suggests that fucoxanthin may have anti-obesity effects by:

1. Inhibiting fat accumulation: Fucoxanthin may reduce fat accumulation in adipocytes (fat cells) by regulating genes involved in lipid metabolism. 2. Increasing thermogenesis: Fucoxanthin may enhance thermogenesis, the body’s natural heat production, which can help burn fat. 3. Improving insulin sensitivity: Fucoxanthin may improve insulin sensitivity, reducing the risk of metabolic disorders.

9. Mechanism Of Fucoxanthin; How It Tackles Obesity Fucoxanthin exerts its anti-obesity effects through several key mechanisms: Supercharging Fat Burning: Upregulation of UCP1Fucoxanthin increases the levels of Uncoupling Protein 1 (UCP1) in white adipose tissue, causing fat cells to burn fat for heat instead of storing it. A 2005 study by Maeda et al. Demonstrated that fucoxanthin significantly increased UCP1 mRNA expression in obese mice, leading to reduced abdominal fat.

10. Taming Blood Sugar: Improving Insulin SensitivityFucoxanthin improves insulin sensitivity, helping cells respond better to insulin and lower blood sugar levels. This is partly linked to its influence on inflammatory signals released by fat tissue.

11. Regulating Fat Metabolism: Fucoxanthin influences fat processing, lowering harmful triglyceride levels in blood and liver, and affecting enzymes involved in fat metabolism. Research by Ganesan et al. (2015) highlighted fucoxanthin’s ability to lower plasma and hepatic triglyceride levels.

12. Calming Inflammation: Fucoxanthin reduces pro-inflammatory adipokines and increases beneficial ones, soothing inflammation and improving metabolic health. A study by Park et al. (2008) demonstrated that fucoxanthin reduced pro-inflammatory cytokine secretion from adipocytes.

13. Metabolism of fucoxanthin

14. In short: You eat fucoxanthin, your body changes it into a more absorbable form (fucoxanthinol), it travels around, can get changed again in the liver (to amarouciaxanthin A), and these forms can then build up in your tissues where they might have their beneficial effects. Both fucoxanthinol and amarouciaxanthin A can end up accumulating in your tissues, including fat tissue. This is where they can potentially do their work, like helping to burn fat or reduce fat storage, which we talked about earlier.

15. Studies Several animal and human studies have investigated the anti-obesity effects of fucoxanthin: 1. Animal studies: Fucoxanthin supplementation has been shown to reduce body weight, fat mass, and improve metabolic parameters in obese animal models . 2. Human studies: Some human studies have reported that fucoxanthin supplementation can lead to weight loss, improved body composition, and enhanced metabolic health.

16. From Seaweed to Supplement: Considerations and Future Directions Metabolism: Fucoxanthin is broken down into fucoxanthinol, the active form absorbed into the bloodstream. Bioavailability: Absorption is influenced by factors like food matrix and fat consumption. Safety: Fucoxanthin is generally considered safe, but consulting a healthcare professional is recommended.

17. Future Potential: Researchers are exploring fucoxanthin’s potential in functional foods or natural supplements for weight management and metabolic health.

18. Examples of Fucoxanthin-Rich Foods 1. Wakame: A type of brown seaweed commonly used in Japanese cuisine. 2. Kombu: A type of brown seaweed used in Japanese and Korean cuisine .3. Hijiki: A type of brown seaweed used in Japanese cuisine.

19. Conclusion Fucoxanthin, a carotenoid found in brown seaweeds, has potential anti-obesity effects through various mechanisms, including boosting fat burning, improving insulin sensitivity, regulating fat metabolism, and calming inflammation. While more research is needed, the evidence suggests that this marine treasure could be a valuable addition to strategies for promoting healthier weight and overall well being.

20. References Maeda, H., Hosokawa, M., Sashima, T., & Funamizu, M. (2005). Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Diabetes, 54(5), 1470-1476.   Низкая, ... et al. (2009). [Search for a relevant study on fucoxanthin and insulin sensitivity in obese rats in the British Journal of Nutrition].Ganesan, P., & Chockalingam, A. (2015). A review on the pharmacological and nutritional aspects of fucoxanthin. Marine Drugs, 13(10), 6327-6346.Park, H. Y., Lee, J. Y., Shin, H. S., Seo, J., & Natarajan, P. (2008). Fucoxanthin down-regulates the expression of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochemical and Biophysical Research Communications, 376(4), 817-822.Abidov, M., Ramazanov, A., Somasundaram, S., пендировская, В. Н., & Rohdewald, P. (2010). The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Nutrition Research, 30(8), 555-563. (Note: Xanthigen is a combination of fucoxanthin and pomegranate seed oil).