ANTI PARKISON DRUGS.pptx

ANTI PARKINSONIAN DRUGS

1. ANTI PARKINSONIAN DRUGS MS.POOJA SEN NURSING LECTURER

2. In clinical practice anti cholinergic drugs, amantadine and the dopaminergic have their primary use of drugs induced Parkinson, acute dystonia and medication induced tremor. Anticholinergics Dopaminergic Monoamine

3. Anticholinergics – Trihexyphenidyl, Benztropine, Biperiden Dopaminergic - Bromocriptine, carbidopa, levodopa Monoamine oxidase type B inhibitor- Selegiline

4. INDICATION Drug induced parkinsonism Acute dystonia Medication induced tremor

5. DOSE 1-2 Mg per day orally initially. Maximum dose up to 15 mg/day in divided dose.

6. MECHANISM OF ACTION It acts by increasing the release of dopamine from presynaptic vesicles, blocking the reuptake of dopamine into presynaptic nerve terminal or by exerting an agonist effect on postsynaptic dopamine receptors.

7. SIDE EFFECT Tachycardia Orthostatic hypotension Dry mouth Nausea Constipation Vomiting Urinary retention and decreased sweating Dizziness Nervousness Drowsiness Weakness Headache Confusion Blurred Vision Mydriasis

8. NURSES RESPONCIBILITY Assess parkinsonian and extrapyramidal symptoms, medication should be tapered gradually. Caution patient to make position changes slowly to minimize orthostatic hypotension. Instruct the patient about frequent rinsing of mouth and good oral hygiene. Caution patient that this medication decreases perspiration and over heating may occur during hot weather.