Anti rheumatic Drugs ,( Pharmacology ppt )

Anti-rheumatoid drugs form a crucial arsenal in the battle against rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by inflammation of the joints. These medications, including Disease-Modifying Anti-Rheumatic Drugs (DMARDs), biologics, and immunomodulators, work by targeting the underlying inflammatory processes that drive RA progression. By suppressing the overactive immune response responsible for joint damage, these drugs not only alleviate symptoms but also aim to halt disease progression and preserve joint function. From traditional agents like methotrexate to cutting-edge biologic therapies such as TNF-alpha inhibitors and JAK inhibitors, anti-rheumatoid drugs offer a spectrum of treatment options tailored to individual patient needs. Understanding their mechanisms of action, potential side effects, and therapeutic benefits is paramount in optimizing the management of RA and improving patients' quality of life."
Cure from the clutches of rheumatoid arthritis with our illuminating presentation on anti-rheumatoid drugs. Dive into the world of disease-modifying agents, biologics, and immunomodulators meticulously crafted to tame inflammation and preserve joint health. Uncover the science behind these therapeutic marvels, their mechanisms of action, and their pivotal role in managing autoimmune disorders. Whether you're a medical professional, researcher, or patient seeking relief, this presentation equips you with essential knowledge to navigate the landscape of rheumatoid arthritis treatment."
Unlock the mysteries of anti-rheumatoid drugs with this insightful presentation. From traditional DMARDs to groundbreaking biologics, delve into the mechanisms and therapeutic effects of these medications in combating rheumatoid arthritis. Explore the latest research, clinical applications, and patient outcomes, empowering your understanding of rheumatologic care. Whether you're a healthcare practitioner, researcher, or patient seeking knowledge, embark on a journey toward clearer comprehension and improved treatment outcomes in rheumatoid arthritis management.

1. Nagpur college of pharmacy Present By :- Ku. Sakshi Ghasle Topic Name :- Antirheumatoid drugs

2. Rheumatoid Arthritis:- Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body’s tissues

3. Symptoms :- * Signs and symptoms of rheumatoid arthritis may include: Tender, warm, swollen joints Joint stiffness that is usually worse in the mornings and after inactivity Fatigue, fever and loss of appetite

4. Early rheumatoid arthritis tends to affect your smaller joints first — particularly the joints that attach your fingers to your hands and your toes to your feet. As the disease progresses, symptoms often spread to the wrists, knees, ankles, elbows, hips and shoulders. In most cases, symptoms occur in the same joints on both sides of your body. About 40% of people who have rheumatoid arthritis also experience signs and symptoms that don't involve the joints. Areas that may be affected include: Skin Eyes Lungs Heart Kidneys Vessel Salivary glands Nerve tissue Bone marrow Blood vessels

5. Risk factors Factors that may increase your risk of rheumatoid arthritis include: Your sex.  Women are more likely than men to develop rheumatoid arthritis. Age.  Rheumatoid arthritis can occur at any age, but it most commonly begins in middle age. Family history.  If a member of your family has rheumatoid arthritis, you may have an increased risk of the disease. Smoking.  Cigarette smoking increases your risk of developing rheumatoid arthritis, particularly if you have a genetic predisposition for developing the disease. Smoking also appears to be associated with greater disease severity. Excess weight.  People who are overweight appear to be at a somewhat higher risk of developing rheumatoid arthritis.

6. Complications :- Rheumatoid arthritis increases your risk of developing: Osteoporosis Rheumatoid nodules.   Dry eyes and mouth.   Infections Abnormal body composition.   Carpal tunnel syndrome.   Heart problems. Lung disease. Lymphoma

7. Antirheumatoid drugs :- Disease modifying anti –rheumatoid grugs ( DMART’S ) Adjuvant drugs Non – Biological Drugs Immuno Suppressants :- Methotrexate Azathioprine Cycloporine Other immuno modulators:- Sulfasalazine Hydroxychloro-quanin Leflubamide Tofacitinif Biological agents TNF – Alfa Inhibitors Etanercept Infliximab Adalimumab Other Biological Anakinra Abatacept Rituximab Prednizolone and other glucocorticoid

8. DMART’S Disease Modifying Anti-rheumatic drugs Methotrexate:- Dihydrofolate reductase inhibitor has immunosuppressive and anti-inflammatory property . To inhibit cytokinin production . Oral low dose (7.4-15 mg ) weekly . First Choice drug . Elimination mainly renal.

9. MTX Adverse effects:- Hepatotoxicity Bone 🦴 marrow suppression. Dispepsia, oral ulcers Teratogenicity

10. TNF :- Tumour necrosis factor:- TNF is a potent inflammatory cytokinin TNF is a produced mainly by macrophages and monocytes. TNF is major contributor to the inflammatory and destructive changes that occur in RA