Anti tubercular drugs dosage adverse effects

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1. ANTI TUBERCULAR DRUGS

2. M. tuberculii 12-13 drugs Highly effective Cheap Easy to adminster Less side effects Bacteriostatic / bactericidal

3. BACTERICIDAL RIFAMPICIN Permeates all membranes inluding blood brain& placental barriers Persistent for dormant bacilli present in lesions Oral drug Daily dose10/12 mg/kg/ day Max 450-600 mg Side effect: nausea, gastritis, nephrotoxicity , purpura , red urine

4. Give empty stomach early morning Absorption reduced by food

5. ISONEX Powerful drug permeates membranes 4-5 mg/kg/day Maximum dose 300mg/day Single dose Side effects GI upset, peripheral neuropathy, hyperglycemia, liver damamge . Pyridoxine( 10-12 mg/day)