Antianginal drug or agent information.pptx

"Anti-anginal drugs are specialized medications used to treat angina pectoris, a condition caused by reduced blood flow to the heart, leading to chest pain or discomfort. These medications work by either increasing oxygen supply to the heart muscle or reducing its oxygen demand. The primary goal of anti-anginal therapy is to relieve symptoms, improve the patient's quality of life, and prevent severe cardiac complications. Common classes of anti-anginal drugs include nitrates, beta-blockers, calcium channel blockers, and newer agents like ranolazine, each targeting different mechanisms to achieve optimal heart health. These medications play a vital role in the management of chronic stable angina as well as acute episodes of pain."
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1. Antianginal Drugs/Agents Jyoti Bind B. Pharmacy

2. Antianginal Drug: Angina Pectoris : -It is symptoms of ischaemic heart disease. -It develops as a result of an imbalance between the oxygen supply and oxygen demand of the myocardium decreases in myocardium perfusion is due to deposition of atherosclerotic plaques in blood result. -This plays are due to accumulation of cholesterol and other liquids compound which develops as patches on inner side of blood vessels. The agents which are used to correct angina pectoris are called as antianginal agent or drug.

3. Adverse Effect: Heart attack : A possible complication of unstable angina Heart failure : A possible complication of unstable angina Stroke : A possible complication of unstable angina Abnormal heart rhythms (arrhythmia) : A possible complication of unstable angina. Cardiac arrest : A rare complication of unstable angina Death : A critical complication of unstable angina

4. Treatment: Blood thinners (antiplatelet medicines) Medicines to control blood pressure, anxiety, abnormal heart rhythms, and cholesterol Angioplasty and stenting Heart bypass surgery Symptoms: A pressing, squeezing, or crushing pain in the chest Pain in the upper back, both arms, neck, or ear lobes Shortness of breath Weakness Extreme tiredness (fatigue) Feeling faint

5. Drugs/Agents: 1.Nitrates: M.O.A : Dilate blood vessels by releasing nitric oxide (NO), which increases cyclic guanosine monophosphate(cGMP) levels, leading to smooth muscle relaxation. Example : Nitroglycerin, Isosorbide dinitrate, Isosorbide mononitrate, Amyl nitrate. 2.Beta-Blockers: M.O.A: Blocks B-adrenergic receptor, reducing heart rate and contractility, there by decreasing myocardial oxygen demand. Example: Propranolol, Metoprolol, Atenolol.

6. 3. Calcium channel blocker : M.O.A: Inhibits calcium influx into cardiac and smooth muscles cells, reducing heart rate and arterial pressure. Example: Verapamil, Diltiazem, Amlodipine. 4. Potassium channel opener: M.O.A: Open potassium channel, causing hyperpolarization and relaxation of vascular smooth muscles, leading to vasodilation. Example: Nicorandil. 5. Other drugs: M.O.A: Various mechanism, including adenosine receptors and other ion channels. Examples: Ranolazine {inhibits late sodium current}, Ivabradine {inhibits if channels}.

7. Thankyou…….