antiasthmatic drug (pharmacology)

classification, MOA, ADRs

1. DRUG ACTING ON RESPIRATORY SYSTEM PRESENTED BY ANJALI RANA

2. TABLE CONTENT Asthma Anti-asthmatic drugs Classification Mechanism Pharmacokinetics Side effects

3. ANTI-ASTHMATIC DRUGS ASTHMA - It is common chronic disorder of airways. spasm of bronchial smooth muscle Increase secretion of mucus-edema & spasm Air locked----decrease tidal air volume Dyspnea ------difficult breathing SYMPTOMS - Difficulty in breathing - Fast Breathing - Shortness of breathing - Fast Heart rate - Chest Pressure - Anxiety

4. ANTI-ASTHMATIC DRUGS These are the agents that are used for the treatment and prevention of asthmatic attack. CLASSIFICATION BRONCHODILATORS a) Sympathomimetic b) Methyl Xanthines c) Anticholinergic Adrenaline Theophylline Atropine Ephedrine Ipratropium bromide Isoprenaline Salbutamol B) Mast cell stabilizers- Disodium Chromoglycate Ketotifen C) Corticosterroids - Beclomethasone dipropionate D) Leukotriene Modulators - Zafirlucast Montelucast

5. MOA OF BRONCHODILATORS Target β -2 receptor in lung airways  when β -2 receptor activated smooth muscles o f airways relaxes Better airflow ADRENALINE- Potent drug, stimulate β -receptor in bronchial smooth muscles  Relieves acute attack & relieves pulmonary congestionProlong use in athma produce Resistance. Side effect- Tachycardia. Contraindication- cardiac asthma, hypertension & hyperthyroidism. SALBUTAMOL- It is a directly acting sympathomimetic drug, used in asthma. Orally administered (tab, syp ). It is available as 2mg, 4mg tab. Side effect- nausea, vomiting, headache,palpitation,tachycardia and muscle Tremor.

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