Antibiotics, common antimicrobials and their classification

Basic antimicrobial agents , classifications and mechanism of action

1. Antibiotics Introduction

2. Intro; Substances produced by microorganisms Inhibits growth of or kills other microorganisms Activity 1 Read and make brief notes on history and development of antibiotics Bactericidal abx vs Bacteriostatic abx

3. Classification of abx based on mechanism of action Cell wall synthesis inhibitors Beta lactams Monobactams glycopeptides Protein synthesis inhibitors Macrolides

4. Aminoglycosides Tetracyclines Lincosamides Streptogramins Linezolid chloramphenicol

5. continuation DNA replication/synthesis inhibitors Sulfa drugs Quinolones Fluoroquinolones metronidazol e

6. Beta lactam antibiotics Penicillins Ampicillin, Amoxycillin, Methicillin, Cloxacillin Cephalosporins 1 st , 2 nd , 3 rd , 4 th 5 th generations 1 st generation Cefazolin, cephalexin, cefadroxil 2 nd generation Cefuroxime, cefaclor, cefoxitin 3 rd generation Ceftriaxone, ceftazidime, cefotaxime

7. Carbapenems Imipenem, meropenem, ertapenem Monobactams aztreonam

8. Protein synthesis inhibitors Tetracyclines 30, g+ve , g- ve Tetracycline, oxytetracycline, doxycycline Aminoglycosides 30s g- ve Streptomycin, neomycin, gentamicin, amikacin Macrolides 50s, g- ve , g+ve Erythromycin, clarithromycin, azithromycin Linsamides Clindamycin 5os , g+ve , lincomycin, Others, linezolids50s , g+ve , chloramphenicol 50s , g- ve , g+ve

9. DNA replication/ synthesis inhibitors Quinolones g- ve , g+ve Natural , nalidixic acid; With fluorine, fluoroquinolones Metronidazole G- ve , g+ve