Antihypertensive alkaloid Rauwolfia serpentina.pptx

Reuwolfia serpentina, reserpine, rececinnamine, ajmaline, fatty acid, unsaturated alcohol

1. Rauwolfia serpentina

2. R a u w o l f i a s e r p e n t i n a

3. Character Plant details Common name- Indian snakeroot, devil pepper, serpentine wood, Sarpagandha , Rauwolfia Serpentina, Chot- chand , Black-snakeroot. Botanical name Rauwolfia serpentina Family Apocyanaceae Native place Shivalik hills of Himalaya

4. Description-

5. Leaves - Simple, opposite arrange in whorls of 3 – 4 to 10 cm long and 5 cm broad Fruits – A re 2 cm in diameterinitially pink in colour and purple when ripe

6. Geographical source-

7. Cork Starch grain Medullary rays Secondary phloem Calcium oxylate crystal phelloderm

8. Cultivation and collection- Climate and Soil- Hot and humid, temp-10- 30 C, , Altitude- 1300 m Plantation- In month of June- July by seed, root, stem Seedlings are transplanted at dist. of 7.5 to 12cm. Organic matter- 25-30 tones per hectare 20 kg Sodium, 30 kg Potassium and 30 kg Phosphorus annually

9. Propagation methods

10. Harvesting and storage-

11. Plant protection-

12. Chemical constituent- About 30 indole alkaloids have reported in root 0.7 to 3% Chemical constituent- Types- Indole alkaloid Indoline alkaloid Indolenine alkaloid oxy indole alkaloid Psedo indoxyl alkaloid Major active constituents- Serpentine, Reserpine Ricinnamine , Ajmaline Ajmalicine Fatty acid, Fumaric acid Unsaturated alcohol

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18. 32 Chemical Tests Freshly fractured surface Conc. HNO 3 Red Colouration along medullary rays Reserpine Vanillin in acetic acid Violet red colour

19. 33 Uses Antihypertensive - Used in Hypertension Tranquilliser - Used in mild anxiety and Neuropsychiatric disorders Used in the treatment of Circulatory disease like obstruction of cerebral blood flow

20. 34 Allied Drugs Rauwolfia tetraphylla Rauvolfia vomitoria Rauwolfia densiflora Rauwolfia perakensis Rauwolfia micrantha

21. Pharmacological action

22. Uses- Antidote against snake bite, venomous reptiles, insects, animal bite In anxiety state, Intestinal disorder, in early stage of pneumonia, fresh juice in eye infection