Antileprotic drugs

anti-leprotic drugs

1. ANTI-LEPROTIC DRUGS Yogapriya.v B.Opt ( IIIyr )

2. INTRODUCTION Leprosy is a disease caused by Mycobacterium leprae Lesions of skin and peripheral nerves are characteristic feature of this disease

3. CLASSIFICATION OF DRUGS SULFONES dapsone ANTITUBERCULAR DRUGS Rifampicin ethionamide PHENAZINES clofazimine ANTIBIOTICS Ofloxacin Minocycline clarithromycin

4. DIAMINO DIPHENYLSULFONE(DDS,DAPSONE) Dapsone are chemically related to sulfonamides It is bacteriostatic It acts by the same mechanism as sulfonamide Absorption,fate and excretion Dapsone are completely absorbed from gastrointestinal tract It is widely distributed in body tissues and fluids A high concentration is present in skin,especially leprosy affected skin It is metabolized by acetylation and also glucuronide and sulfate conjugation The metabolic products are eliminated in urine

5. Adverse effect Sensitisation of skin leading to exfoliative dermatitis Hemolysis in patients with G-6-PD deficiency Blood dyscrasias like agranulocytosis Hypothyroidism and goiter Preparation and dose Tablets of dapsone are administered at a dose of 100mg daily

6. RIFAMPICIN It is bactericidal antibiotic which is effective orally It has no serious adverse effects But it imparts an orange red color to urine,saliva and other secretions Dose 600 mg for two consecutive days in a month

7. ETHIONAMIDE It is a fast acting drug than dapsone But it is more expensive and more toxic It is orally effective and it is administered daily CLOFAZIMINE It is a phenazine dye with an anti-inflammatory effect It has a weak bactericidal action It can br used in dapsone resistant leprosy,tuberculoid leprosy,for relieving pain of lepra reaction It produces reddish black color on the skin

8. ANTIBIOTICS Antibiotics such as ofloxacin,minocycline and clarithromycin are tried in the treatment of leprosy They are tried in monotherapy or in multidrug therapy They can be used in cases either allergic or resistant to dapsone

9. LEPRA REACTION The acute exacerbation which occurs during the course of leprosy is called as lepra reaction It occurs due to various factors like infections,malaria or treatment with sulfones Lepra reactions are treated with clofazimine or chloroquine Dapsone is not withdrawn but continued in full doses throughout lepra reactions

10. THANK YOU FOR LISTENING 