Antipsychotic Drugs.pptx

Psychoses, Classification, SAR and mode of action of anti-psychotic drugs are described.

1. Antipsychotic Drugs By Dr. Nidhi Gupta M.M. University, Mullana , Ambala, India

2. Antipsychotics Antipsychotics , also known as  neuroleptics  or  major tranquilizers , are a class of medication primarily used to manage  psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Antipsychotics are usually effective in relieving symptoms of psychosis in the short term.

3. Thioridazine Piperacetazine Trifluoperazine Chlorprothixene Thiothixene

4. 24 MECHANISM OF ACTION There are many type of DA-receptors (see upper). The antipsychotic drugs probably owe their therapeutic effects mainly to blockade of D2 receptors. The main groups, phenothiazines, thioxanthines and butyrophenones, show preference for D2 over D1 receptors; some newer agents (e.g. remoxipride) are highly selective for D2 receptors, whereas clozapine is relatively non-selective between D1 and D2, but has high affinity for D4. DA, the naturally occurring agonist, interacts with D1 and D2 receptors, and both receptors are found in high density in the corpus striatum and nucleus accumbens. Most striatal neurons have D1 responses and most accumbens neurons have D2 responses.

5. 25