Antitubercular drug poster 2020 including MOA

Antitubercular drugs

1. TRANSMISSION A n infectious bacterial disease characterised by the growth of NODULES in the tissues especially lungs. CULPRIT: Mycobacterium tuberculosis The bacteria usually attack the lungs,but TB bacteria can attack any part of the body INTRODUCTION

2. : Isoniazid[H],Rifampicin[R],Pyrizinamide[Z], Ethambutol[E],Streptomycin[S] Fluoroquinolones:Ofloxacin,Levofloxacin,Moxifloxacin, Ciprofloxacin Other oral drugs :Ethionamide,Prothionamide, Cycloserine,Terizidone,Rifabutin, Para-aminosalicyclic acid,Thiacetazone Injectable drugs: :Kanamycin,Amikacin, Capreomycin TB DRUG CLASSIFICATION SECOND LINE TB DRUG FIRST LINE TB DRUGS H EAR A CT L EARN T REAT TUBERCULOSIS

3. MECHANISM OF ACTION OF TB DRUG I SONIAZID: Disrupts the synthesis of cell wall in M.Tuberculosis RIFAMPIN: Inhibit RNA synthesis PYRAZINAMIDE: Inhibit mycolic acid synthesis ETHAMBUTOL: Inhibit arabinosyl transferases involved in arabinogalactan synthesis thereby interfering with mycolic acid incorporation in mycobacterial cell wall STREPTOMYCIN: Disrupts the protein synthesis CYCLOSERINE: Interfers with cell wall synthesis ETHIONAMIDE: Inhibit synthesis of mycolic acid PAS: Inhibition of folate synthesis