_Apparent Volume of Distribution.....pdf

Handwritten Notes of B pharm 6th semester -3 year ( UNIT 1) Biopharmaceutics & Pharmacokinetics

1. BiobhamocaubeA k Pharnnacobinuhiu
Apharant Volumu d Distribuhon
in chlai on
But
distributas to vaYioWb org on% and Hsues
when th brous d distnikuion comþlte (a 2gubibrium)
dbifunt orqons and tissus cantain
X
X
As dillunt isuus havs diluunt comuntrahon of drug
veLlumu d distikukon ton nof, kav tuu
þhyilogiad maoning
0 tostant elaionshbib betueen
plasma drug canuntrahi¡n C
and
Uni!1
amount d drug in th body X
e C
= Va C
uhu Vo : þroporhionality
GP604T
callud
So rom abovs aquaion
Vd
constant
Dr. Parjanya Shukla
Dr. M. P. Sngh Clas
abporent valumu d ditnibution
L-9
Aþparznt Valum d Disribiukion -Amaunt o drug in body
Plaama dvuq comentrahion.
dulind os tke bybo thuhtal valum d tho body luid
into whith o drag i6 disolud or distbutid.
(8)

2. * J is call d os ahpornt volum. bataust all
body 2qulibratud wih ha chua
LQua con u nrah'on.
þorta PT
do
Re
nof hove
Ked Valom ddistikuion'
* udl valum o distibukon kas d'ud phyiologikal maorúng
Plaid Compont menis of a 70 Kg A dalt
Body lid
ulat1d to body oahar.
J. VasuaY wdblood (Plasma)
2. &xhoellwar Plusd
(exduiding þlasma )
3. InhocaluJor P'd
(excuding Alood culls)
Total Body Oaker (T6W)
Valume
(itras)
6
I7
’ Thh exBzo alllar uid (ECe) volum
Body wuight
34
Dr. Parjanya Shukla
60
Dr. M. P. Sngh Classes
TOW
but do not croBs ul mumbronu
15
Valumy d thess ua þhysio Jogi cal tomþormants can b
dalumind by wse o 'shuaihe trouvs or mokers.
bs
57
ioo
’ h blasmo voluma ’ by Aubatan us dbigh mala udar
iaght or toallyto plasmo þrotin.
Evons bluu, indo cyani n gLon ,I-13| albumin,
by kubsancas that Jasily CrOBB cabiory mambronu
’

3. for exampu -Not, u, Br, SCN. and 80,2
and inuin, mannitoJ ond alinose
(none ol hess comþlabdly kabt out si du
’ Total Body watey (TBw) valume
by subsonus Rat Dgually distbudes n al oater
compantments d ti body (both intra k exra cwlalor)
Por exomþl -heovy w ahr CDa0)
tri tHated waty (HTO) and
Dr. Parjanya Shukla
Dr. M. P. Singh Cla0ES
bid solubh Aubsonus Auch as antipyine.
* Intraulwor olum is defumined
difeonu bjw TBW and ECE vouma.
((9)