Applications of ir spectroscopy pharma tutor

instumentation in pharmacy

1. 1/3/2017 APPLICATIONS OF IR SPECTROSCOPY | PharmaTutor
http://www.pharmatutor.org/pharma­analysis/analytical­aspects­of­infra­red­spectroscopy­ir/application­ir­spectrophotometry 1/4
 
Vacancies (http://www.pharmatutor.org/pharma-jobs/vacancies.html) Crack GPAT (http://www.pharmatutor.org/exam-alert/gpat/prepare-for-gpat-online)
Articles (http://www.pharmatutor.org/articles) Pharma News (http://www.pharmatutor.org/pharma-news)
Pharma Quiz (http://pharmatutor.org/taxonomy/term/2876)
 
Projects (http://www.pharmatutor.org/pharma-projects)
 
(/)
(/)
QUICKLINKS
Latest News
 
Zydus acquires six brands from MSD (http://www.pharmatutor.org/pharma-news/2016/zydus-acquires-six-brands-from-msd)
 
(https://docs.google.com/forms/d/18XN56fuXwSUVc1RUIrvxCJC0JIObNkr2naqnojy4UpU/viewform)
APPLICATIONS OF IR SPECTROSCOPY
(http://www.pharmatutor.org/exam-alert/gpat/prepare-for-gpat-online)
            APPLICATIONS OF IR
SPECTROSCOPY
Infrared spectroscopy is widely used in industry as well as in research. It is
a simple and reliable technique for measurement, quality control and
dynamic measurement. It is also employed in forensic analysis in civil and
criminal analysis.
Some of the major applications of IR spectroscopy are as follows:
1. Identification of functional group and structure elucidation
Entire IR region is divided into group frequency region and fingerprint
region. Range of group frequency is 4000­1500 cmwhile that of finger
print region is 1500­400 cm.
In group frequency region, the peaks corresponding to different functional
groups can be observed. According to corresponding peaks, functional
group can be determined.
Each atom of the molecule is connected by bond and each bond requires
different IR region so characteristic peaks are observed. This region of IR
spectrum is called as finger print region of the molecule. It can be
determined by characteristic peaks.
Home (/) » APPLICATIONS OF IR SPECTROSCOPY
11
­1 
­1
Regus Offices Pakistan.No Hidden Costs & Flexible Options. Workspaces To Suit. Get A
Quote Now Go to regus.pk/Pakistan­Office­Space
IR Spectroscopy
IR Infrared
Ads byGoogle
PreviousPauseNext
(https://www.facebook.com/pharmatutor/)(https://twitter.com/pharmatutor)(http://www.pharmatutor.org/rss.xml)(https://play.google.com/store/apps/details?
id=com.pharmatutor&hl=en)
(https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewSoftware?
id=1076348182&mt=8)

2. 1/3/2017 APPLICATIONS OF IR SPECTROSCOPY | PharmaTutor
http://www.pharmatutor.org/pharma­analysis/analytical­aspects­of­infra­red­spectroscopy­ir/application­ir­spectrophotometry 2/4
Tags: Pharma Analysis (/taxonomy/term/2076)
IR Spectroscopy (/taxonomy/term/2220)
2. Identification of substances
IR spectroscopy is used to establish whether a given sample of an organic
substance is identical with another or not. This is because large number of
absorption bands is observed in the IR spectra of organic molecules and
the probability that any two compounds will produce identical spectra is
almost zero. So if two compounds have identical IR spectra then both of
them must be samples of the same substances.
IR spectra of two enatiomeric compound are identical. So IR spectroscopy
fails to distinguish between enantiomers.
For example, an IR spectrum of benzaldehyde is observed as follows.
C­H stretching of aromatic ring­                        3080 cm
C­H stretching of aldehyde­                              2860 cmand 2775 cm
C=O stretching of an aromatic aldehyde­         1700 cm
C=C stretching of an aromatic ring­                  1595 cm
C­H bending­                                                     745 cm and 685 cm
No other compound then benzaldehyde produces same IR spectra as shown
above.
3. Studying the progress of the reaction
Progress of chemical reaction can be determined by examining the small
portion of the reaction mixure withdrawn from time to time. The rate of
disappearance of a characteristic absorption band of the reactant group
and/or the rate of appearance of the characteristic absorption band of the
product group due to formation of product is observed.
4. Detection of impurities
IR spectrum of the test sample to be determined is compared with the
standard compound. If any additional peaks are observed in the IR
spectrum, then it is due to impurities present in the compound.
5. Quantitative analysis
The quantity of the substance can be determined either in pure form or as
a mixure of two or more compounds. In this, characteristic peak
corresponding to the drug substance is chosen and log I0/It of peaks for
standard and test sample is compared. This is called base line technique to
determine the quantity of the substance.
 
­1
­1  ­1
­1
­1
­1 ­1
A­Z
Nanoparticles/Nano
powdersElement, Carbide, Nitride &
Oxide; Carbon Nanotubes,
Graphene & Dispersions. nanoamor.com
FT IR
Chemistry
Ads byGoogle
­ 35 Hours Ago
Recruitment for M.Pharm/Ph.D (36 posts) at
Indian Pharmacopoeia Commission - govt job |
emolument upto Rs.1 lakh per month
(http://www.pharmatutor.org/content/december-
2016/job-for-mpharm-phd-indian-
pharmacopoeia-commission-as-
pharmacopoeia-scientists)
­­­
Recruitment for M.Pharm, M.Sc at Defence
Institute of Bio-Energy Research - 18 posts |
Government of India, Ministry of Defence
(http://www.pharmatutor.org/content/december-
2016/recruitment-for-mpharm-msc-at-defence-
institute-of-bioenergy-research)
­­­
Job for B.Pharm, M.Pharm as ECG Analyst
Trainee at CHC Healthcare | 100 posts
(http://www.pharmatutor.org/content/december-
(http://www.skysa.com/?
rf_id=3)
 Site Announcements _X

3. 1/3/2017 APPLICATIONS OF IR SPECTROSCOPY | PharmaTutor
http://www.pharmatutor.org/pharma­analysis/analytical­aspects­of­infra­red­spectroscopy­ir/application­ir­spectrophotometry 3/4
(http://www.pharmatutor.org/magazines/subscribe)
 
Search PharmaTutor
Enter your email address:
Subscribe

Do Not Forget to Verify
(Click on Subscription link in your inbox)
SUBSCRIBE WITH US
(http://www.pharmatutor.org/articles/iim-lucknow-and-
glocal-healthcare-cphm)
A­Z
Nanoparticles/Nanopowder
s ­ Standard & Customized
Adnanoamor.com
ELECTRONIC TRANSITION
IN UV VISIBLE
SPECTROSCOPY
pharmatutor.org
Chromatec Crystal 9000 ­
Hi­End GC & GC­MS
instruments
Adchromatec­instruments.comNEXT
TOP
­ 35 Hours Ago
Recruitment for M.Pharm/Ph.D (36 posts) at
Indian Pharmacopoeia Commission - govt job |
emolument upto Rs.1 lakh per month
(http://www.pharmatutor.org/content/december-
2016/job-for-mpharm-phd-indian-
pharmacopoeia-commission-as-
pharmacopoeia-scientists)
­­­
Recruitment for M.Pharm, M.Sc at Defence
Institute of Bio-Energy Research - 18 posts |
Government of India, Ministry of Defence
(http://www.pharmatutor.org/content/december-
2016/recruitment-for-mpharm-msc-at-defence-
institute-of-bioenergy-research)
­­­
Job for B.Pharm, M.Pharm as ECG Analyst
Trainee at CHC Healthcare | 100 posts
(http://www.pharmatutor.org/content/december-
(http://www.skysa.com/?
rf_id=3)
 Site Announcements _X

4. 1/3/2017 APPLICATIONS OF IR SPECTROSCOPY | PharmaTutor
http://www.pharmatutor.org/pharma­analysis/analytical­aspects­of­infra­red­spectroscopy­ir/application­ir­spectrophotometry 4/4
Production Jobs
(http://www.pharmatutor.org/taxonomy/term/1770)
R&D Jobs
(http://www.pharmatutor.org/taxonomy/term/1884)
F&D Jobs
(http://www.pharmatutor.org/taxonomy/term/1998)
Sales & Marketing
(http://www.pharmatutor.org/taxonomy/term/1888)
QA Jobs
(http://www.pharmatutor.org/taxonomy/term/1869)
QC Jobs
(http://www.pharmatutor.org/taxonomy/term/1764)
Faculty Jobs
(http://www.pharmatutor.org/taxonomy/term/2172)
CRO Jobs
(http://www.pharmatutor.org/taxonomy/term/2109)
DRA Jobs
(http://www.pharmatutor.org/taxonomy/term/2005)
IPR Jobs
(http://www.pharmatutor.org/taxonomy/term/1841)
IT Jobs
(http://www.pharmatutor.org/taxonomy/term/2238)
Walk-in Jobs
(http://pharmatutor.org/taxonomy/term/2513)
Government Jobs
(http://www.pharmatutor.org/taxonomy/term/2558)
Hosptial Pharmacist
(http://pharmatutor.org/taxonomy/term/1912)
BROWSE BY JOBS
QUICK LINKS
TOP
­ 35 Hours Ago
Recruitment for M.Pharm/Ph.D (36 posts) at
Indian Pharmacopoeia Commission - govt job |
emolument upto Rs.1 lakh per month
(http://www.pharmatutor.org/content/december-
2016/job-for-mpharm-phd-indian-
pharmacopoeia-commission-as-
pharmacopoeia-scientists)
­­­
Recruitment for M.Pharm, M.Sc at Defence
Institute of Bio-Energy Research - 18 posts |
Government of India, Ministry of Defence
(http://www.pharmatutor.org/content/december-
2016/recruitment-for-mpharm-msc-at-defence-
institute-of-bioenergy-research)
­­­
Job for B.Pharm, M.Pharm as ECG Analyst
Trainee at CHC Healthcare | 100 posts
(http://www.pharmatutor.org/content/december-
(http://www.skysa.com/?
rf_id=3)
 Site Announcements _X