Aspirin, Clopidogrel and Ticagrelor Mechanisms.pptx

Aspirin, Clopidogrel and Ticagrelor Mechanisms

1. Aspirin, Clopidogrel and Ticagrelor Mechanisms of Action dr. Yusuf Wibisono, Sp.S(K), Sp.Akp.

2. ASPIRIN MECHANISM OF ACTION Kevin Janitra Iechang

3. Thromboxane A2 Platelet aggregation Vasodilatation COX 1 PLATELET Arachidonic Acid Aspirin Phospholipids Membrane Phospolipase A2 Blocked the activity of COX-1 (+) platelet aggregation Vasoconstrictor

4. CLOPIDOGREL / TICAGRELOR MECHANISM OF ACTION Kevin Janitra Iechang

5. P2Y12 RECEPTOR α i Activation of fibrinogen-binding protein GPIIb/IIIa & COX-1 Platelet aggregation Adenylate cyclase PLATELET A deno diphospate VAS P TICAGRELOR / CLOPIDOGREL Phospholipids Membrane Activate Adenylate cyclase BLOKCED the P2Y12 Receptor cAMP Activation of fibrinogen-binding protein GPIIb/IIIa & COX-1 Platelet aggregation Platelet aggregation cAMP VASP -P

6. TICAGRELOR MECHANISM OF ACTION Kevin Janitra Iechang

7. ADP Adenylate cyclase α i ATP cAMP VASP VASP-P P Activation of fibrinogen-binding protein GPIIb/IIIa & COX-1 Platelet aggregation Adenylate cyclase PLATELET ADP VASP-P P VASP TICAGRELOR P2Y12 RECEPTOR DIRECT ACTING NON COMPETITIVE AND REVERSIBLE

8. CILOSTAZOL MECHANISM OF ACTION