atherosclerosis and dyslipidemia (vascular).ppt

Atherosclerosis is primarily a progressive disease of intima involving large and medium-sized elastic
and muscular arteries. It is characterized by focal lipidrich intimal lesions called atheromas (atheromatous or
atherosclerotic plaques).
Epidemiology: Atherosclerosis is a worldwide disease seen
in both developed and developing countries.
The word atherosclerosis is derived from Greek for “gruel”
(atheroma) and “hardening” (sclerosis).

1. DYSLIPIDEMIA
AND
ATHEROSCLEROSIS
Professor Jean-Charles Fruchart
Department of Atherosclerosis (Inserm UR545)
Pasteur Institute of Lille
University of Lille II
France

2. Cardiovascular disease is the leading cause
of death among adults worldwide (1996)
Coronary disease 7.2 million
Cancer 6.3
Cerebrovascular disease 4.6
Acute lower respiratory tract infections3.9
Tuberculosis 3.0
COPD (chronic obstructive pulmonary disease)2.9
Diarrhea (including dysentery) 2.5
Malaria 2.1
AIDS 1.5
Hepatitis B 1.2

3. Coronary mortality:
alarming worldwide forecasts

4. Atherosclerosis:
a multifactorial disease

5. Main risk factors for coronary heart disease

6. Global projections for the diabetes epidemic:
1995-2010

7. Atherosclerosis