Ativisha by Saket.pptx for Dravyguna Dept NCISM

Ativisha -Aconitum Heterophyllum best ailment in Pediatrics (Ayurved)

1. ATIVISHA BY SAKETKUMAR SRIVASTAVA ,36,2 nd BAMS DEPT OF DravYAGuna, K.G. MITTAL AYURVED COLLEGE

2. TABLE OF CONTENTS Useful Parts With Its Rasapanchaka Karma,Agryakarma And Dosha Karma Amayikaprayoga used in Vyadhi (Disease) pertaining to various Srotas and Vyadhiavastha (Stage) Kalpana (dosage form) Matra (Dose) Anupana (Vehicle) • Marga (Route) • Oral and Lepa kalpana (Poisonous bites and shotha ) Sevana kala (Time of administration) • ( Madhyabhakta - D,Muhurmuhu -V,C,K) Kalavadhi (Duration) • Pathya-apathya •

3. TABLE OF CONTENTS Active Phyto -constituents Important Formulations Research Updates
Botanical Name & Family Main Synonyms & Vernacular Names
External Morphology- Habit, Root, Leaf, Stem, Flower, Inflorescence, Fruit, Seed Officinal Useful Parts
Varieties Grahyagrahyatwa Adulterants & Substitute Toxic Effects

4. Useful Parts With Its Rasapanchaka प्रयोग अंग : Tuberous Root PRABHAV-VISHAHARA

5. Karma,Agryakarma And Dosha Karma Karma- Kasahara , Jwarahara , Deepana , Pachana , Vishaghana , Chardighana , Krimighana Agryakarma-Charak-अतिविषा दीपनीय पाचनीय साङ्ग्राहिक सर्वदोषहराणाम् | Doshakarma - Kapha - Pitta Hara Kapha Hara because of Ushna Virya and Katu Vipaka .
Pitta Hara because of Tikata Rasa.

6. Amayikaprayoga used in Vyadhi (Disease) pertaining to various Srotas and Vyadhiavastha (Stage) Agnimandya Atisara Jwara Ajeerna Kasa Krimi Chardi Visha Roga Bala Roga Action on Dhatu Ras : Jvaraghna , As thi , Majja : Shothhar Meda : Lekhan , Deepan , Pachan Action on Mala: Grahi Action on Strotas : Annavaha: Deepan , Pachan,Agnideepan Medovah : Medoghna

7. Amayikaprayoga Vishakta (Poisoning): Ghee cooked with Ativisha along with the milk of cow, etc. is beneficial as intake or snuff in case of poisoning. Similar is, in effect, cooked with Shweta and Madayantika . ( Shusruta Samhita Kalpa Sthana . 1/64) The paste of Ativisha taken with honey is efficacious in rat- poisoning. ( Shusruta Samhita Kalpa Sthana . 7/39) Bala Roga (Children's disease): In case of cough, fever, and vomiting Ativisha is given singly with honey or combined with Karkatsharngi and Pippali . ( Ashtanga Hridya Uttara Tantra . 2/ 57, Vrinda Madhava . 66/10). C haturbhadr Avaleha (Bhava Prakasha Chikitsa Sthana . 71. 151), in addition, contains Mustaka .

8. Amayikaprayoga Atisara (Diarrhea): Ativisha Avaleha containing Ativisa along with Bilva , Mocharasa , Lodhra , Dhataki - Puspa , and mango-seed, checks for severe diarrhea. (Bhava Prakasha Samhita Chikitsa Sthana . 2/148) Liquid gruel processed with Ativisha and Sunthi is efficacious is Ama Atisaara . ( Charaka Samhita Sutra Sthana . 2/22) Grahani Roga (IBS) : In Grahani - Roga , the decoction of Ativisha, Shunthi , and Mustaka is given to digest Ama . ( Charaka Samhita Chikitsa Sthana . 15/98) Ankota 3 parts and Ativisha 1 part mixed are taken with water. It checks all abdominal disorders. ( Vanga Sena Grahani . 167)

9. The Shishu Bhaishajya (Best Remedy for Children’s Ailments)

10. ACTIVE PHYTO-CONSTITUENTS In tubers, atisine content varies from 0.19% to 0.27%. However, 0.79% of total alkaloids of the plant are found in tubers. Other alkaloids found in A. Heterophyllum are heteratisine (0.3%), histisine , heterophyllisine , heterophylline , heterophyllidine , atidine , and hitidine . Also present are aconitic acid, tannic acid, a mixture of oleic, palmitic , and stearic acids, glycerides, and vegetable mucilage in addition to starch and sugars . (Source : Vikaspedia Portal by Ministry of Electronics and Information Technology ( MeitY )

11. Important Formulations Ativishadi Churna for Kasa , Jwara Mahatiktaka Ghrita for Pittaja Kustha Pushyanaga Churna for Arsha and Atisaara Vasishta Haritaki for Kasa Rodhra Asava for Prameha Madhukadi Ghrita for Arsha and Atisaara Bal Chaturbhadradi Churna for Bala Roga Kutajghan Vati Chandraprabha Vati Khadir Gutika

12. Research updates on ATIVISHA Aconitum heterophyllum appeared to stimulate phagocytic function while inhibiting the humoral component of the immune system. Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin.; Preliminary screening. J. Ethnopharmacol . 1986 Nov; 18 (2): 133-41. Ayurvedic substitution pair: Musta (Cyprus rotundus L., Cyperaceae ), a common weed, for the rare Himalayan species, Ativisha (Aconitum heterophyllum Wall. Ex Royle ; Ranunculaceae ). Observations indicate that Ayurveda may attach more importance to the pharmacological properties of raw drugs than to their botanical classification. Venkatasubramanian P, Kumar SK, Nair VS. Cyperus rotundus , a substitute for Aconitum heterophyllum : Studies on the Ayurvedic concept of Abhava Pratinidhi Dravya (Drug substitution). J Ayurveda into. Med. 2010 Jan; 1 (1): 33-9. Anti-inflammatory
Anti-bacterial
Immune-modulatory Antihyperlipidemic Carminative

13. Botanical Name & Family Botanical Name Aconitum heterophyllum Wall.
Aconitum – Aconite Heterophyllum – with dissimilar leaves Family Ranunculaceae ( Vatsanabha Kula)

14. Main Synonyms & Vernacular Names According to Habitat काश्मीराः – कश्मीरे भवा |
The plant grows in Kashmir. माद्री – मद्र देशे भवा ।
Plants grow in Madra Desha .
According to Appearance शुक्ल कंदा – शुक्ल वर्णः कन्दो अस्य ।
Root tubers are white. श्रृंगी – शृङ्गाकार कन्द त्वात ।
Root tubers are horn-shaped. According to properties and action पित्त वल्ल्भा - पित्त रोगे फल प्रदा। Ativisha is efficacious in Pittaja Roga . घुण वल्लभा - आशु घूणैः संसृज्यते। Root tubers are quickly infested. अतिसारघ्नी - अतिसारं नाशयति। Ativisha is very useful in Atisara. शिशु भैषजयं - बाल रोगेषु लाभ प्रदा। Ativisha is very beneficial in pediatric disorders. विषा - विवेष्टि व्याप्नोति शरीरं अथवा विषम हन्ति। It spreads throughout the body or is useful as an antidote. शोफापहा - शोफ नाशिनी। It cures Shopha.Some other synonyms of Ativisha are as follows:Sugandha , Vishda , Visharupa , Chandri , etc .

15. Main Synonyms & Vernacular Names Indian Atees (English) Ataich (Bengali) Ativish (Gujarati) Atees , Atish , Atis , Patis (Hindi) Atibaje (Kannada) Astividayam (Malayalam) Ativisa (Marathi) Batis (Punjabi) Atividyam (Tamil) Atibasa (Telugu) Bajjturaki (Persian)

16. External Morphology

17. VARIETIES Vagbhata mentioned two varieties Ativisha & Visha ( Visha dvaya A. S. Su.12. and A. H. Ut. 39/79) Sodhala described three varieties Shukla ( Sweta ), Krishna & Aruna ( Shodhala Nighantu Guna Sangraha . 12) and Madanadi Nighantu quoted four varieties Rakta (red tubers), Shweta (white tubers), Krishna (black tubers) & Pita (yellow tubers) varieties.
Several authors identified Visha dvaya as A. Heterophyllum and A.Palmatum ( Guruprasad Sharma & P. V. Sharma). A. Palmatum root is black- colored and hard in texture. Regarding three or four varieties of Ativisha further work is necessary. It may be one of the adulterants, A. Kashmiricum is the third variety as described in the Nighantus , while Delphinium denudatum ( Nirvisha ) may be the fourth variety.
Botanically three varieties of Ativisha are observed:
Aconitum heterophyllum,Aconitum palmatum,Aconitum kashmiricum

18. Grahyagrahyatwa No Classic Reference regarding Grahyalakshana was found. Quality accessment of Aconitum Heterophyllum is mostly on the basis of amount of active Phyto -constituents present in the sample assessed by Metabolomics, or evaluating its phytochemistry .

19. Adulterants & Substitute Cyperus rotundus L. ( Musta ) C. Scariosus R. Br. Cyperaceae Cryptocoryne spiralis (Retz.) Fisch . Ex Wydler Araceae (Country Ativisha).

20. Toxic Effects

21. THANKING DEPARTMENT OF DRAVYAGUNA KGMAC Vd.Balaji Sawant (HOD) Vd.Janhavi Alwe ( Asso.Prof .) Vd.Shraddha Chaudhari ( Asst.Prof .)

22. PHARMACOLOGY Atisine (I) is much less toxic than aconitine and pseudaconitine and consequently the species is often regarded as non-poisonous. Although the alkaloid atisine produce hypotension the whole aqueous extract of the root induced marked hypertension apparently through an action on the sympathetic nervous system. It is now confirmed that the alkaloid atisine is the important constituent of A. Heterophyllum which acts as antiperodic aphrodisiac and tonic aconitine has action as the CNS CVS and respiratory system due to the presence of benzyl ester and OH-groups in the molecular structure this system is present is present in the polyesters of celastrus paniculatus and these esters have got similar action as aconitine . The similarity the biological activities of the two ayurvedic drugs viz A. Heterophyllm and celastrus paniculatus ( Jyotismati ) ,may perhaps help the future pharmacologists to deep into the subject.