Developing countries: more
Both sexes
All age groups
Prevalence rate: 46 per thousands (rural), 16 per
thousands (urban)
3
4
It is also called unsafe or dangerous type of
CSOM, because dangerous intra-or-extracranial
complications can occur
In this the disease spreads to bony walls of
epitympanum, aditus, antrum and adjoining
mastoid cells.
Associated with cholesteotoma.
Risk of complications is higher
5
6
Cholesteatoma
Osteitis and granulation tissue
Osteitis involves outer attic wall, posterosuperior margin
of tympanic ring
Granulation tissue surrounds it may even fill the attic,
antrum, posterior tympanum, mastoid
Fleshy red polypus: meatus
7
Ossicular necrosis
Destruction may be limited to the long process of incus,
may also involves stapes superstucture, handle of malleus/
entire ossicular chain
Greater hearing loss
Cholesteatoma hearer
Cholesterol granuloma
Mass of granulation tissue with foreign body giant cells
surrounding the cholesterol crystals.
8
MISNOMER:
Neither it contains cholesterol crystals
Nor it is benign neoplasia to merit suffix “oma”
Various names have been given to it such as:
Cholesteatosis(Young)
Epidermosis(1961, Tumarkin)
Keratosis (1963, McGuckin)
Keratoma(1974, Schuknecht), which is thought to be
most appropriate.
9
Skin at a wrong place is the simplest definition
of cholesteatoma.
It may be defined as a cystic structure lined by
keratinized squamous epithelium resting on a
fibrous stroma
Consists of two parts
Matrix-Keratinizing squamous
epithelium resting on thin fibrous tissue
central white mass-keratin debris
produced by matrix
10
Macroscopically cholesteatoma looks like a soft
pultaceous mass resembling tooth paste
contained in a sac or cholesteatoma appears to be
a rounded pearly white mass often surrounded by
friable granulation tissue from infected bone
Microscopically cholesteatoma is a benign
keratinizing squamous cell cyst
Epithelial matrix of acquired cholesteatoma has
10 to 15 layers, while congenital cholesteatoma
has only 5 layers of matrix
11
Insimplerterms,cholesteatomaissquamous
epitheliuminanabnormalsiteinthemiddleear
whichpossessesboneerodingproperties.
Theboneerosionisduetotwothings
a) Pressure effects produced by bone
remodelling,
b)Enzymaticactivityatthemarginsofthe
cholesteatoma which greatly
increasesthespeedofboneerosion.
Thelevelsoftheseosteoclasticenzymesincreasein
thepresenceofbacterialinfection.
12
Because of repeated infections, squamous metaplasia of
the low cuboidal epithelium of the middle ear occurs
This subsequently leads to development of cholesteatoma
This theory did not find much favor.
21
22
CONGENITAL
ACQUIRED
PRIMARY
SECONDARY
Embroyonic epidermal cell rests in the middle ear cleft/
temporal bone
Middle ear, petrous apex,cerebellopontine angle
Middle ear: white mass behind an intact tympanic
membrane -> conductive hearing loss
Discovered: routine exam/myringotomy
May spontaneously rupture-TM -> discharging ear
23
24
No h/o previous OM/ pre-existing perforation
Invagination of pars flaccida
Persistent negative pressure in the attic -> retraction
pocket which accumulates keratin debris.
Infected -> expand -> middle ear
Basal cell hyperplasia
Proliferation of the basal layers of PF induced by
subclinical childhood infection
Squamous metaplasia
Normal pavement epithelium of attic undergoes
metaplasia, keratinizing squamous epithelium
25
Already a pre-existing perforation in pars tensa
Associated with posterosuperior marginal perforation
Migration of squamous epithelium
KSE of EAC/ outer surface of TM migrates through the
perforation into the middle ear
Metaplasia: repeated infections of middle ear-preexisting
perforation
26
27
28
29
30
Invades surrounding
structures.
Bone destruction by
various enzymes.
Collagenases
Acid phosphatase
Proteolytic enzymes
Cause destruction of ear
ossicles, erosion of bony
labyrinth, canal of facial
nerve, sinus plate, tegmen
tympani.
Causes serious
complication.
32
DISCHARGE:
Scanty
Purulent
Foul-smelling
Blood-stained
Continuous
not associated with
URTI.
Mostly conductive
May be sensorineural.
Sometimes normal as
cholesteotoma bridges
gap caused by destroyed
ossicles (Cholesteotoma
hearer)
HEARING LOSS:
PERFORATION:Attic or postero-
superior.
DISCHARGE:Purulent, foul-smelling,
blood-stained.
CHOLESTEOTOMA.
RETRATION POCKETS.
TUNING FORK TESTS:Show
conductive or sensorineural hearing loss.
33
34
35
GRADE I:Normal position of TM.
GRADE II:TM touches long process of incus.
GRADE III:TM touches promontory.
GRADE IV:TM adheres to promontory.
36
37
38
GRADE I:Minimal retraction.
GRADE II:Pars flaccida in contact with neck of
malleus.
GRADE III:Limited outer attic wall erosion.
GRADE IV:Severe outer attic wall erosion.
39
SURGICAL
CANAL WALL UP
CANAL WALL DOWN
RECONSTRUCTIVE SURGERY
Myringoplasty/ tympanoplasty
Primary surgery/ 2nd stage procedure
CONSERVATIVE
52
53
CANAL WALL
DOWN
PROCEDURES.
Atticotomy.
Radical
Mastoidectomy.
Modified Radical
Mastoidectomy.
CANAL WALL UP
PROCEDURES.
Cortical
Mastoidectomy.
Combined
Approach
Tympanoplasty.
A canal wall down procedure performed
to remove all or part of outer attic wall
and adjacent deep posterior meatal wall
to expose the attic and when necessary
the aditus and antrum in order to gain
access to these sites and their contents
and/or remove disease limited to these
sites.
54
A canal wall down procedure in which
we remove all disease from mastoid and
middle ear by lowering bridge making it
a single cavity, remove all ossicles except
foot-plate of stapes, remove remains of
tympanic membrane, obliterate the
eustachian tube, and exteriorized this
cavity to EAM by doing meatoplasty.
55
A canal wall down procedure in which
we remove disease from mastoid and
middle ear by lowering bridge making it
a single cavity, remove only diseased
ossicles, donot remove remains of
tympanic membrane, donot obliterate the
eustachian tube, and exteriorized this
cavity to EAM by doing meatoplasty.
56
57
A canal wall up procedure performed
to remove disease from mastoid antrum
and air cell system and aditus &
antrum, with preservation of an intact
posterior bony external auditory canal
wall, without disturbing the existing
middle ear contents.
58
59
Operation performed to remove disease
from middle ear and mastoid by way of
a)Mastoid.
b)Posterior Tympanotomy.
c)Transcanal route.
followed by reconstruction of middle
ear transformer mechanism.
60
An operation performed to eradicate
disease in the middle ear and to
reconstruct the hearing mechanism,
without mastoid surgery, with or without
tympanic membrane grafting.
61
Cholesteatoma is small, easily accesible to suction
clearance under microscope
Elderly >65 years old
Unfit for GA/ refused
Polyps,granulation tissue: cup forceps/ cauterized by
chemical agents (silver nitrate/ trichloroacetic acid)
Aural toilet, dry ear precautions
62