B Pharm final year project caffeine and menthol mouth spray

B pharma final year project

1. PrepareandsubmitCaffeineandmentholcontainingmouthsprayfororalulcers
submittedtoCHHATTISGARHSWAMIVIVEKANANDTECHNICALUNIVERSITY,BHILAI(C.G.)RAINNG.
BachelorofPharmacySubmittedbyBPharm8thsemesterMR.RATNESHKUMARRATREYRollNo.301504120079EnrollmentNo:BJ3403Undertheguidance.
Ms.Preetichandrakar
SHRIRAWATPURASARKARINSTITUTEOFPHARMACYKUMHARIDURG(C.G)2023-24

2. DECLARATIONItheundersignedsolemnlydeclarethatthereportsoftheprojectentitledis"Caffeineandmentholcontainingmouthsprayfororalulcers"basedonmyworkcarriedoutduringthecourseofmystudyunderthesupervisionofMs.PreetichandrakarIassertthatthestatementmadeandconclusionsdrawnareanoutcomeofmyKnowledgeandbeliefthereportdoesnotcertainanypartofanyworkwhichhasbeensubmittedforthedegreeofBachelorinthisuniversity.
RatneshKumarRatreyRollNo.-301504120083EnrollmentNo.-BJ3403SRIPKumhariDurgCG.
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3. CERTIFICATEThisistocertifythatMr.RatneshKumarRatreyinB.pharm8thSemesterinthisdepartmentisperformingherprojecton"Caffeineandmentholcontainingmouthsprayfororalulcer"AndhassubmittedasatisfactoryprojectforpartialfullfilmentofthedegreeofBachelorofPharmacy,toChhattisgarhSwamiVivekanandTechnicalUniversity,Bhilai.
Place:KumhariDate:Ms.Preetichandrakar(Guide)Assist.Professor (ExternalExaminer)
Mr.BhushanMuleyProfessorandPrincipalofS.R.I.P.Kumhari,Durg
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4. ACKNOWLEDGEMENTAfewwordsofgratitudewrittenonsheetofpapercannevercompletelydescribemyfeelingsforthepeopleinvolvedinthesuccessfulcompletionofmyproject.ItisamatterofprofoundprivilegeandpleasuretoextendmysenseofrespectanddeepestgratitudetomyprojectguideAssistantprofessorunderwhosepreciseguidanceandgraciousencouragement
Ihadtheprivilegetowork.IacknowledgewithdeepsenseofresponsibilityandgratitudethesupportgivenbyrespectedMr.BhushanMuleysir,Principal,ShriRawatpuraSarkarinstituteofPharmacy,KumhariDurgIalsoliketothankmanypeopleinourcollege,facultymembersofPharmacyDepartmentandsupportingstaff,foralwaysbeinghelpfulovertheyears:
Lastbutnottheleast,Iwouldliketoexpressour/mydeepestgratitudetomyrespectedparentsandmanagementofShriRawatpuraSarkarInstitueOfPharmacyfortheircontinuousmoralsupportandencouragement,Ihope,tomakethemproudofmyachievements,asIamproudofthem.Theirloveaccompaniesus/mewhereverIgo.
Name:-RatneshKumarRatreyRollNo.:301504120083EnrollmentNo.-BJ3403
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5. TABLEOFCONTENTSS.no. ContentsPage11.11.21.31.4
IntroductionTypesofulcersCausesofulcerSymptomsTreatmentandmanagement
6788822.12.1.12.1.22.22.2.12.2.2
DrugprofileCaffeineMechanismsofactionUseMentholMechanismsofactionUse
9910101111123AimandObjectives1244.14.24.34.44.54.6
MethodIngredient&ApparatusSelectionWeighingandMeasuringSolubilizationandMixingAdjustmentofpHandViscosityPackagingandLabeling
1313
141515165DosageandAdministration16

6. 6Evaluation178Result189Conclusion1910Reference20
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7. 1IntroductionOralulcers,alsoknownasmouthulcersorcankersores,arepainfullesionsthatcandeveloponthemucousmembranesofthemouth.Theycanoccurontheinnercheeks,lips,gums,tongue,ortheroofofthemouth.Theseulcersareacommonoralhealthissueandcanaffectindividualsofallages.
Fig.no.1
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8. 1.1TypesofulcersAphthousUlcers:Thesearethemostcommontypeoforalulcersandareoftenreferredtoascankersores.Theyaretypicallysmall,roundoroval-shapedlesionswithawhiteoryellowcenterandaredborder.TraumaticulcersTheseulcersresultfromphysicalinjuryortraumatothemouth,suchasaccidentalbiting,dentalprocedures,oraggressivebrushing.HerpeticUlcers:Causedbytheherpessimplexvirus,theseulcersareoftenassociatedwitwthecoldsoresandmayoccuronthelipsorinsidethemouth.
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9. 1.2CausesofulcersAphthousulcers:Theexactcauseisunknown,butfactorssuchasstress,hormonalchanges,certainfoods,andunderlyinghealthconditionsmaycontributetotheirdevelopment.Traumaticulcers:Resultfrommechanicalinjurytotheoralmucosa.Herpeticulcers:Causedbytheherpessimplexvirus(HSV-1orHSV-2)andarehighlycontagious.
1.3SymptomsPainordiscomfort,especiallywheneatingordrinkingSensitivitytospicyoracidicfoodsRednessandinflammationaroundtheulcerDifficultyspeakingorbrushingteeth,dependingontheulcer'slocation
1.4TreatmentandmanagementTopicalmedicationssuchasoralgels,mouthrinses,mouthsprayorpatchestoreducepainandpromotehealingAvoidingirritatingfoodsorsubstancesthatcanexacerbatesymptomsMaintaininggoodoralhygienepracticesManagingunderlyingconditionsortriggers,ifapplicable
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10. 2Drugprofile2.1CaffeineCaffeineisanaturalstimulantfoundinvariousplants,includingcoffeebeans,tealeaves,andcacaopods.Knownforitsabilitytoenhancealertness,concentration,andmood,caffeineiswidelyconsumedworldwide.Beyonditsstimulatingproperties,caffeinealsoexhibitsantioxidantandanti-inflammatoryproperties,whichmaycontributetoitstherapeuticeffectsinoralhealth.
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11. 2.1.1MechanismsofactionAnti-InflammatoryPropertiesCaffeine:Actsasanadenosinereceptorantagonist,inhibitingtheinflammatoryresponsebyreducingtheproductionofpro-inflammatorycytokinesandmediators.
2.1.2Use•Diuretic•Foodadditive•Adjuvant•CNSstimulant•Painrelief•Motivation/Productivity,Neurologicalconditions
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12. 2.2Menthol
Fig.no.-3Mentholisacompoundderivedfrommintplants,suchaspeppermintandspearmint.Renownedforitscoolingsensation,mentholisoftenusedintopicalproductstorelievepainandsootheirritatedskinormucousmembranes.Mentholalsopossessesanalgesicandanti-inflammatoryproperties,makingitapopularingredientinoralcareproductsforitsnumbingandrefreshingeffects.
2.2.1MechanismsofactionMenthol:Exhibitsanti-inflammatoryeffectsbymodulatingtheactivityofTRPM8receptors,whichareinvolvedinpainandinflammationsignalingpathways.AnalgesicEffectsCoolingSensation
PromotionofHealing,EnhancedDrugDelivery
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13. 2.2.2UseSoothestheliningofthedigestivetract,SunburnTreatmentCoughMedicines,Decongestant,Antipruritic,TopicalAnalgesic
3AimPrepareandsubmitCaffeineandmentholcontainingmouthsprayfororalulcersIntroduction:Ourcaffeineandmentholmouthsprayformulationoffersatargetedapproachtoprovidingrapidreliefandpromotinghealingfororalulcers.Inthissection,wewilldelveintothekeycomponentsandfeaturesofourinnovativemouthsprayformulation.
ObjectiveIncreasetherecoveryofinfectionandinjuryIncreasethedrugactivityIncreasethedrugsafetyandeffecy
Activepharmaceuticalingredient(api)caffeine,mentholExcipientsandCarriers:propyleneGlycol:Servesasasolventandcarrierfortheactiveingredients,ensuringuniformdispersionandoptimaldeliverytotheaffectedareasoftheoralmucosa.Glycerin:Enhancesmouthfeelandprovideslubrication,promotingcomfortandeaseofapplication.Ethanolactsasapreservativeandenhancesthesolubilityofcaffeineandmenthol,facilitatingtheirrapidabsorptionandonsetofaction.Pageno.12

14. FormulationStabilityandShelfLife:Ourmouthsprayformulationundergoesrigorousstabilitytestingtoensureconsistencyinpotency,efficacy,andsensoryattributesoveritsshelflifeAcombinationofpackagingmaterialsandformulationtechniquesisemployedtoprotecttheintegrityoftheactiveingredientsandextendtheproduct'sshelfstability.
4Method4.1Ingredient&ApparatusSelection-(i)Choosepharmaceutical-gradecaffeineandmentholforoptimalpurityandefficacy.(ii)Selectexcipientsandcarrierssuchaspropyleneglycol,glycerin,andethanolbasedontheirsolubility,stability,andcompatibilitywiththeactiveingredients.(iii)Apparatus-Weighmachine,beaker,Measuringcylinder,glassrodetc.
Figno.4Weighingaingredients
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15. Formulationtableof100ml.S.no.IngredientsConcentrationQuantity12CaffeineMenthol1-5%0.1-1%2gm1gm345
6
Glycerin.Ethanol.Propyleneglycol.Citricacid.
10-20%10-50%10-30%
PHadjust
20ml35ml29ml
Q.S.
4.2WeighingandMeasuring-(i)accuratelyweighandmeasureeachingredientaccordingtothepredeterminedformulationformula.(ii)Ensureprecisemeasurementstomaintainconsistencyanduniformityinthefinalproduct.
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16. 4.3solubilizationandMixing–(i)Dissolve2gmcaffeineandmenthol1gmintheappropriatesolvent(e.g.,propyleneglycol)tocreateahomogeneoussolution.(ii)Utilizegentleheatingoragitationasneededtofacilitatedissolutionandensureuniformmixinginpropyleneglycol29ml
. Fig.no.-6
(iii)Addglycerin20mlmixingthoroughlybetweenadditionstoensureproperdispersionandcompatibility.
4.4AdjustmentofpHandViscosity–(i)MonitorthepHandviscosityoftheformulationandadjustasnecessarytomeetthedesiredspecifications.(ii)UsepH-adjustingagents(e.g.,citricacid,sodiumhydroxide)andviscositymodifiers(e.g.,hydroxyethylcellulose)asrequiredtoachievethedesiredsensoryandperformancecharacteristics.
4.5EthanolIncorporation-Graduallyaddethanol35mltotheformulation,takingcaretomaintainpropermixingandhomogeneity.
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17. 4.6PackagingandLabeling-Transferthefinishedmouthsprayformulationintoappropriatepackagingcontainers,suchasspraybottlesorpumpdispensers.Labelthecontainerswithessentialinformation,includingproductname,activeingredients,dosageinstructions,precautions,andexpirationdate.
5DosageandAdministrationEachspraydeliversaprecisedosageoftheformulationtotheaffectedarea,allowingforconvenientandtargetedapplication.Usersareinstructedtoshakethebottlewellbeforeuseandspraydirectlyontotheoralulcer,ensuringthoroughcoverageformaximumeffectiveness
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18. 6EvaluationConductqualitycontroltestsontheformulation,includingpHmeasurement,viscositydetermination,andvisualinspectionforuniformityandclarity.
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19. 7ResultCaffeineandmentholcontainingmouthsprayfororalulcershasbeenpreparedandsubmitted.
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20. 8ConclusionOurcaffeineandmentholmouthsprayformulationrepresentsanovelapproachtomanagingoralulcersymptoms,offeringrapidreliefandsupportforthehealingprocess.Withitscarefullyselectedingredients,precisedosagedelivery,andcommitmenttoqualityandsafety,ourmouthsprayprovidesaconvenientandeffectivesolutionforindividualsseekingrelieffromoralulcerdiscomfort.
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21. 9Reference:-1.B.Clarke,J.W.Timmis,N.G.ReillyPublishedin:EuropeanJournalofAppliedPhysiology,vol.115,no.10,pp.2263-2274,2015.2.Pfister,W.,Ghosh,T.,2005.Intraoraldeliverysystems:Anoverview,currentstatusandfuturetrends.In:Ghosh,T.,Pfister,W.(Ed.),Drugdeliverytotheoralcavity:moleculestomarket.Taylor&Francis,CRCPress,Florida.pp.1-34.3.DanaraddiS,KoneruA,HunasgiS,RamaluS,VanishreeM.Naturalwaystopreventandtreatoralcancer.JOralResRev.,2014;6:34-9.4.Carrillo,J.A.,andBenitez,J.2000.Clinicallysignificantpharmacokineticinteractionsbetweendietarycaffeineandmedications.Clin.Pharmacokinet,39:127-153.5.GaryW.Arendasha.b,andChuanhaiCaob.c.2010."CaffeineandCoffeeasTherapeuticsAgainstAlzheimer'sDisease"JournalofAlzheimer'sDisease20117-1266.LuR,DanH,WuR,MengW,LiuN,JinXetal.Lycopene:Featuresandpotentialsignificanceintheoralcancerandprecancerouslesions.JOralPatholMed.,2011;40:361-8.7.HaskóG.LindenJ.CronsteinB,PacherP(September2008)."Adenosinereceptors:therapeuticaspectsforinflammatoryandimmunediseases".NatRevDrugDiscov7(9):759-70.doi:10.1038/nrd2638.PMC2568887.PMID18758473.
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