Base analog

base analogs related to DNA

1. BASE ANALOGS BIBHU PRASAD RATH LECT. IN BOTANY

2. Which one of the following is a base analogue [BHU 1984] A) Nitrous acid B) Colchicine C) 5 - bromouracil D)  Caffeine acycloguanosine

3. Base analogues are molecules that can substitute for normal bases in nucleic acids. Base analogs  are molecules which have a very similar structure to one of the four nitrogenous  bases  which are used in DNA (adenine, guanine, cytosine or thymine). 5-bromouracil

4. Usually, substitution of a base analogue will result in altered base pairings and structural changes that affect DNA replication and transcription of genes. 5-bromouracil, 2-aminopurine, 6-mercaptopurine, and acycloguanosine 2-aminopurine

5. Since 5-bromouracil can pair with either adenine or guanine, it also affects base pairing during DNA replication, which leads to mutations. An analogue of adenine, 2-aminopurine, also causes mutations in a similar way since it can pair with either T or C . 6- mercaptopurine

6. Neoplasm, a new and abnormal growth of tissue in a part of the body, especially as a characteristic of cancer . 5-Bromouracil is used to treat neoplasms. Image courtesy : https://en.wikipedia.org/wiki/Neoplasm